Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis.
Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.
Rezensionen / Stimmen
"I highly recommend this book to all organic chemists in industry and academia, but particularly those in development and production. Not only is it an excellent reference work, it is also a thumping good read!" Peter Spargo, Organic Process Research & Development "This book is a must for process developers, and is of interest to both chemists and biochemists...Moreover, the book is easy and relaxing to read, and the variety of topics invites browsing." "Dieses Buch ist ein "Muss" fur Prozessentwickler, wobei nicht nur Chemiker, sondern auch Biochemiker angesprochen sind...Daneben labetat sich das Buch auch "einfach so" gut lesen, die Vielfalt der Themen ladt geradezu zum Schmokern ein!" Rainer Sturmer, BASF AG, Ludwigshafen Angewandte Chemie + IE 20/04
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Chemische Industrie, Katalyse-Chemiker, Industriebibliotheken, Institutsbibliotheken
Illustrationen
290
70 s/w Tabellen, 290 s/w Abbildungen
Illustrations
Maße
Höhe: 24 cm
Breite: 17 cm
Dicke: 28 mm
Gewicht
ISBN-13
978-3-527-30631-2 (9783527306312)
Schweitzer Klassifikation
Hans-Ulrich Blaser carried out this doctoral research with A. Eschenmoser at the Federal Institute of Technology (ETH) Zurich, from which he received the Ph.D. degree in 1971. Between 1971 and 1975 he held postdoctoral positions at the University of Chicago (J. Halpern), Harvard University (J.A. Osborn), and Monsanto (Zurich). During 20 years at Ciba0Geigy (1976-1996) he gained practical experience at R&D in the fine chemicals and pharmaceutical industry, which continued at Novartis (1996-1999) and at Solvias where he presently is chief technology officer. During his industrial career he has developed and implemented numerous catalytic routes for agrochemicals, pharmaceuticals and fine chemicals both as project leader and section head. His main interests are focused on (enantio) selective catalysis and the integration of catalytic steps into the syntheses of commercial products. Elke Schmidt carried out her doctoral research with Prof. Christian Wandrey at the Institute for Biotechnology (Nuclear Research Center) in Juelich. She received her Ph.D. degree in 1987 from the Institute for Chemistry of the Rheinische Friedrich Wilhelm University, Bonn. During the last 16 years at Ciba-Geigy, Norvatis and Syngenta, she held various positions in R&D, during the last 10 years in Crop Protection Research. Her main interest is focused on biotransformation, natural products discovery and fermentation development for small molecules and proteins.
Asymmetric hydrogenation: The Monsanto L-dopa process
The other l-dopa process
The Chiral Switch of Metolachlor: The Development of a Large Scale Enantioselective Catalytic Process
An Innovative Asymmetric Sulfide Oxidation: The Process Development History behind the New Antiulcer Agent Esomeprazole
Enantioselective Hydrogenation: Towards a Large-Scale Total Synthesis of Chiral Terpenoid Compounds
Comparison of Four Industrial Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate
7-Aminocepholasporanic acid - chemical vs. enzymatic production process
Methods for the Biocatalytic Production of L-Amino Acids on Industrial Scale
The large-scale biocatalytic synthesis of enantiopure cyanohydrins
Industrialization Studies on the Jacobsen Hydrolytic Kinetic Resolution of Racemic Epoxides
Scale-up studies in asymmetric transfer hydrogenation
Practical Applications on Biocatalysis or the Manufacturing of Chiral alcohols such as (R)-1,3-butanediol by Stereo-specific Oxidoreduction
Microbial resolution of 2,3-dichloro-1-propanol and 3-chloro-1,2-propanediol
Synthesis of Unnatural Amino Acids
The Application of DuPHOS Rhodium(I) Catalysts for Commercial Scale Asymmetric Hydrogenation
(TMBTP) Ruthenium catalysts: a useful tool for industrial asymmetric hydrogenations
Biocatalytic approaches for large scale production of asymmetric synthons
Master the scale-up of catalytic asymmetric hydrogenations for the manufacture of fine chemicals
Large-Scale Applications of Biocatalysis in the Asymmetric Synthesis of Laboratory Chemicals
Development of an Efficient Synthesis of Chiral 2-Hydroxy Acids
Factors Influencing the Application of Literature Methods Toward the Preparation of a Chiral trans-Cyclopropane Carboxylic Acid Intermediate During Development of a Melatonin Agonist
Hetero Diels-Alder - Biocatalysis Approach for the Synthesis of (S)-3-[2-{(Methylsulfonyl) oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol Methanesulfonate: Successful Application of an Enzyme Resolution Process
Multi kilo resolution of XU305, a key intermediate to the platelet glycoprotein Iib/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution
Protease-Catalyzed Preparation of (S)-2-[(tert-Butylsulfonyl)methyl]-hydrocinnamic Acid for Renin Inhibitor RO0425892
Protease-Catalyzed Preparation of Chiral 2-Isobutyl Succinic Acid Derivatives for Collagenase Inhibitor RO0319790
Development of a Biocatalytic Process for the Resolution of (R)- and (S)-Ethyl 3-amino-4-pentynoate Isomers Using Enzyme Penicillin acylase
