Efforts of many workers in the field of Pain research over the past few years to design novel analgesics have, unfortunately not significantly increased the availability of real new drugs for the pharmacological treatment of pain. Morphine (or related agonists) remains the most effective remedy to relieve severe pain, despite some very real progress made in pain management over the past decade. The development of new experimental models of clinical pain appears to be essential. Many data suggest great potential for using the noradrenergic modulation either at central or even at peripheral levels. However it appears from the present book, that basic scientists and clinicians should be prudent before definitive conclusions. A detailed listing of the papers provided in this publication is provided hereunder.
Efforts of many workers in the field of Pain research over the past few years to design novel analgesics have, unfortunately not significantly increased the availability of real new drugs for the pharmacological treatment of pain. Morphine (or related agonists) remains the most effective remedy to relieve severe pain, despite some very real progress made in pain management over the past decade. The development of new experimental models of clinical pain appears to be essential. Many data suggest great potential for using the noradrenergic modulation either at central or even at peripheral levels. However it appears from the present book, that basic scientists and clinicians should be prudent before definitive conclusions. A detailed listing of the papers provided in this publication is provided hereunder.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
Maße
Gewicht
ISBN-13
978-0-444-89582-0 (9780444895820)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Ascending pain pathways with special reference to the spino(trigemino)-ponto- amygdaloid tract (J.F. Bernard and J.M. Besson). The segmental control of pain (A.H. Dickenson and L.C. Stanf). Descending control systems: Physiological aspects (W.D. Willis). Descending control system: General pharmacological considerations (A.W. Duggan). Anatomical studies of the noradrenergic projection to the spinal cord dorsal horn (A.I. Basbaum). Anatomy of noradrenergic pathways modulating pain (K.N. Westlund). The behavioural pharmacology of the noradrenergic descending system (H.K. Proudfit). Interactions between monoaminergic and opioidergic systems (G.F. Gebhart). Effects of noradrenergic agonists on animal chronic pain models: Arthritic and mononeuropathic rats (V. Kayser, J. Desmeules and G. Guilbaud). Noradrenergic receptors in the dorsal horn of the spinal cord (P.M. Headley). The antinociceptive effects of noradrenergic agonists on the activity of the spinal dorsal horn neurones (S.M. Fleetwood-Walker). The spinal noradrenergic systems in the transmission of pain in patients (C.J. Glynn). Antidepressants and relief of neuropathic pain: Evidence for noradrenergic mechanisms (R. Dubner and M.B. Max). Is there a place for alpha2 adrenergic agonists in the control of pain? (H.J.McQuay). Towards the use of noradrenergic agonists for the treatment of pain (J.M. Besson and G. Guilbaud).
