Somatostatin, a peptide hormone initially isolated from ovine hypthalami, has been documented to inhibit the release of growth hormone. It soon became evident that this peptide was not only present in the brain but also widely distributed in the stomach, the gastrointestinal tract and the pancreas. In the mid-1980s, a synthetic analogue of somatostatin, octreotide, became widely available and has been instrumental in the treatment of acromegaly and in several clinical areas relating to gastroenterology and digestive surgery. This text examines the role of somatostatin-analogues in gastrointestinal diseases, and includes such topics as the role of octreotide and somatostatin in the treatment of intestinal fistulae, and somatostatin or octreotide in acute variceal bleeding.
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ISBN-13
978-3-8055-6878-4 (9783805568784)
Schweitzer Klassifikation
A decade of octreotide; somatostatin and octreotide - physiological background and pharmacological application; the role of octreotide in the treatment of gastroenteropancreatic endocrine tumours; the role of octreotide in the prevention of complications following pancreatic resection; the role of octreotide and somatostatin in acute and chronic pancreatitis; somatostatin or octreotide in acute variceal bleeding; octreotide in the treatment of refractory diarrhoea; treatment of acute nonvariceal upper gastrointestinal haemorrhage; role of octreotide and somatostatin in the treatment of intestinal fistulae; outlook.
