In this title, an extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the "Modern Endocrinology Series", this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.
In this title, an extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the "Modern Endocrinology Series", this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.
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Höhe: 254 mm
Breite: 178 mm
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ISBN-13
978-0-7817-1496-9 (9780781714969)
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Schweitzer Klassifikation
1. Principles of Endocrine Genetics 2. Transgenic Animal Models of Pituitary Function 3. Insulin Dependent Diabetes (Type I) 4. Ectopic Pituitary Hormone Production 5. Molecular Genetics of Human Growth Disorders Related to the GH:IGF-I Axis 6. Molecular Pathogenesis of Pituitary Failure (Pit-1 Mutations) 7. Sexual Differentiation 8. Autoimmune Thyroid Disease 9. Disorders Affecting Parathyroid Hormone 10. Endocrine Dependent Cancer: MEN I and II 11. Laboratory Evaluation and Screening of Genetic Endocrine Diseases 12. G-protein Abnormalities in Endocrine Diseases 13. Type 2 Diabetes Mellitus 14. Polycystic Ovary Syndrome: Candidate Genes for Hyperandrogenism and Hyperinsulinemia 15. The Genetics of Obesity 16. Pituitary Tumor Pathogenesis 17. Diabetes Insipidus 18. Genetics of Adrenal Steroid Disorders 19. Genetics of Sex Determination 20. Disorders of Thyroid Hormones Synthesis 21. Disorders Affecting the -Subunits of Pituitary Glycoprotein Hormones 22. Genetic Disorders of Parathyroid Hormone Action 23. The Vitamin D Endocrine System: Metabolism, Mode of Action, and Genetic Evaluation 24. Genetic Disorders of Skeletal Mineral Metabolism 25. Principles of Gene Therapy 26. Knockout Mice and Transgenic Mouse Models of Endocrine Disorders 27. Genetic Disorder of Lipid Transport 28. Pituitary Hormone Gene Regulation 29. Hypothalamic Releasing Hormone Receptors: Structure and Function 30. Endocrine Sensitive Cancers of the Prostate and Breast 31. Resistance to Glucocorticoid and Mineralocorticoid Hormones 32. Androgen Resistance and Disorders of Androgenic Metabolis
