The ultrastructural basis of capillary permeability.- Structural and functional polarity of the blood-brain barrier.- Active and facilitated amino acid transport mechanisms across the brain capillary endothelial cells in physiological and pathological condition.- Central noradrenergic innervation of cerebral microvessels: implications for an autonomic nervous system within the brain.- Innervation of the cerebral vasculature and its putative role in the coupling of flow to metabolism.- Peptidergic innervation of the cerebral vasculature and its functional significance.- Neurotransmitter coupled responses in the microvasculature of the brain under normal and pathological conditions.- Physiological and pathological events mediated by capillary neurotransmitter receptors.- Biochemical changes of brain microvessels during aging.- Experimental models of ischemia.- Mechanisms of ischemic damage to neurons, glial cells and vascular tissue.- Dynamic variations of the extracellular space in the central nervous system.- Role of glial cells in the control of the neuronal microenvironment.- Functional interactions between neurons and glial cells.- Alteration of the blood-brain-barrier by components of the immune system.- Relationships between neuronal activity, energy metabolism and cerebral circulation.- Measurement of regional hemodynamic and metabolic changes in the central nervous system with imaging techniques.- Use of positron emission tomography to study patterns of brain metabolism in relation to age and disease: a correlation matrix approach.
