This book gathers together chemical ideas which are important for understanding how drugs act and how new drugs may be developed. Students meet some of these ideas in courses in chemistry, biochemistry and pharmacology but in my experience they find it difficult to put together information often acquired in different years and from different departments; they need it set out in a book. I believe also that it helps if they can see how these ideas may be applied to numerical problems so I have included examples (with answers), many of which are taken from research work. These should therefore provide a chance for the student both to test his or her own understanding and to see the sort of results which form the bricks of which any experimental science is made. In all the problems the arithmetic takes less than ten minutes with a small calculator which has exponential functions and logarithms.
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Research
Illustrationen
Maße
Höhe: 216 mm
Breite: 140 mm
Dicke: 15 mm
Gewicht
ISBN-13
978-0-7099-0300-0 (9780709903000)
DOI
10.1007/978-1-4684-8332-1
Schweitzer Klassifikation
1. Measuring Drug Activity.- Measuring the Effects of Drugs: 'Responses'.- Assessing Biological Activity.- Application of Bioassay Methods to the Comparison of Drugs.- Types of Drug Action.- 2. Physicochemical Problems.- Rates of Reaction and Positions of Equilibrium.- Solubility.- Volume of Dilution.- Rate of Removal.- Rate of Absorption.- Partition Coefficients and Crossing Membranes.- Relations between Reaction Rates and Equilibrium Constants.- 3. The Size and Shape of Molecules.- Size: Molal Volumes and Apparent Molal Volumes.- Shape.- Isomerism.- Optical Rotation.- Stereochemical Purity and Biological Activity.- Description of the Arrangements of Groups about an Asymmetric Carbon Atom.- Preferred Conformations.- 4. Chemical Processes where Size and Shape are Important.- Adsorption.- Adsorption of Two Species.- Enzyme and Substrate.- The Need for Other Models.- Agonists and Receptors.- Rate Theory.- Desensitisation of Receptors.- Forces between Drug and Receptor.- 5. The Prediction of Drug Activity.- Nonspecific Activity.- Homologous Series.- Biological Activity and Chemical Properties: the Ideas of Hansch.- Is Affinity Predictable?.- Conclusion.- Appendix: Line-fitting by the method of least-squares.- Answers to Examples.
