Part 1 Biological rhythms in principle: basic concepts and implications, J.Arendt et al; an introduction to chronopharmacology, G.W.Aherne. Part 2 Biological rhythms in practice: endocrine rhythms, Eve Van Cauter; circadian rhythms in the cardiovascular system, Bjorn Lemmer; circadian rhythms in the respiratory system, Peter J.Barnes; urinary and renal circadian rhythms, M.Koopman et al; clinical immunology and allergy, Francis Levi et al; circadian rhythms of plasma amino acids, brain neurotransmitters and behaviour, Peter Leathwood; the relationship between biological rhythms and the affective disorders, Stuart Checkley; melatonin and the pineal gland, J.Arendt; circadian rhythms in general practice and occupational health, D.S.Minors and J.Waterhouse; preclinical and clinical cancer chronotherapy, W.J.M.Hrushesky et al; present achievements and future prospects for clinical chronobiology, M.H.Smolensky; analysis of biological time series, D.S.Minors and J.Waterhouse.