Part 1 Assessment of xenobiotic-induced nephrotoxicity: isolated renal cells in the study of nephron heterogeneity and nephrotoxicity, L.H. Lash; the use of cultured renal epithelial cells "in vitro" assessment of xenobiotic-induced nephrotoxicity, G. Gstraunthaler and W. Pfaller; epithelial cell fusion of normal and pH-transformed madin darby canine kidney cells - new tool for studying mechanisms of carcinogenesis, H. Oberleithner; NMR - a tool for the study of renal function and nephrotoxicity, B.D. Ross and J.C. Bellinger. Part 2 Renal disposition of xenobiotics: interaction of xenobiotics with organic anion and cation transport systems in renal proximal tubule cells, K.J. Ullrich, et al; renal transport of heavy metals, E.C. Foulkes; renal transport and metabolism of mercapturic acids and their precursors, the S-conjugates of glutathione and cysteine, S. Silbernagl and A. Heuner; renal xenobiotic metabolism - role in bioactivation of nephrotoxic xenobiotics. Biactivation and nephrotoxicity of xenobiotics, M.W. Anders and W. Dekant; bioactivation of halogenated xenobiotics by S-conjugate formation, W. Dekant, et al; a2h-globulin-related nephrotoxicity, E.A. Lock; cyclosporin A induced nephrotoxicity - current concepts and controversies, P.H. Whiting; the renal tubular transport and nephrotoxicity of beta-lactam antibiotics, B.M. Tune; the nephrotoxicity of heavy metals, W.O. Berndt; the nephrotoxicity of anticancer drugs, R.F. Borch; hormone-induced nephrocarcinogenicity, M. Metzler; nephrocarcinogenicity of haloalkenes and alkynes, S. Vamvakas, et al.