Cytokines are soluble molecules which act as messengers in immune and inflammatory responses intercellularly. The group includes interleukins, colony stimulating factors, tumour neurosis factors and interferons. It has recently been realized that they act not alone, but in a complex network to control haemopoiesis, allergic and inflammatory responses, infection and shock, tumour development, wound repair and more. This chemical reference discusses the basic classification, structure, source and general functions of cytokines and then applies this to chemical situations, discussing cytokines both in terms of pathogenesis and treatment. The book also: emphasizes the network effort of cytokines; explains this cutting-edge science in terms of day-to-day medical practice; classifies the complex field of cytokines in terms of structure, source and function; discusses their role in infection, immunology, endocrinology, metabolism and cancer; and reflects the trend towards the biotherapy of disease.
Auflage
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
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Maße
Höhe: 279 mm
Breite: 216 mm
Gewicht
ISBN-13
978-0-86542-352-7 (9780865423527)
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Schweitzer Klassifikation
Part 1 Cytokines network: common and uncommon features of cytokines and cytokine receptors - an overview. Part 2 Role of cytokines in immunoregulation: role of cytokines in haematopoiesis; role of cytokines in lymphocyte function; role of cytokines in the activation of monocytes; role of cytokines in neutrophil function; role of cytokines in mast cell function; role of cytokines in endothelial cell functions; role of cytokines in the regulation of hypersensitivity responses; role of cytokines in graft vs host reaction and rejection following allogeneic bone marrow transplantation; role of cytokines in organ transplant rejection; role of cytokines in autoimmune diseases; role of cytokines in multiple sclerosis/autoimmune encephalitis and other neurological disorders; role of cytokines in rheumatoid arthritis. Part 3 Cytokines as modulators of physiological function: role of cytokines in lipid metabolism and cachexia; role of cytokines involved in acute phase response; role of cytokines in glucose metabolism; role of cytokines in regulation of bone remodeling and osteoporosis; role of cytokines in hypothalamic-pituitary function; role of cytokines in sleep, fever and anorexia; role of cytokines on thyroid; role of cytokines in ovarian physiology - interleukin-1 as a possible centerpiece in the ovulatory sequence; role of cytokines in oxidation damage; the role of cytokines in aging. Part 4 Role of cytokines during infection: role of cytokines/lymphokines in gram-positive bacterial infections; role of cytokines in septic shock and shock.
