Part 1 The framework: national innovation systems, Richard R. Nelson; national innovation systems and instituted processes, John de la Mothe and Gilles Paquet; regional innovation - in search of an enabling strategy, Zoltan J. Acs, John de la Mothe and Gilles Paquet. Part 2 European Studies: business processes in regional and innovation systems in the European Union, Philip Cooke; innovation systems and "local difficulties" - the Oxfordshire experience, Helen Lawton Smith; university-industrial relationships in Germany and their regional consequences, Rolf Sternburg. Part 3 North American studies: regional networks and innovation in Silicon Valley and Route 128, AnnaLee Saxenian; universities in local innovation systems, Attila Varga; towards a conceptualization of super regional systems of innovation, Rebecca Morales. Part 4 Technology Management: sources of innovative environments - a technological evolution perspective, James M. Utterback and Allan N. Afuah; network models for technology-based growth, Edward J. Malecki; venture capital's role in regional innovative systems - historical perspective and recent evidence, Donald R. Smith and Richard Florida. Part 5 The city and the world: the learning region, Richard Florida; cities, information and "smart holes", Zoltan J. Acs and John de la Mothe.