At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry. Since its very beginning, research in this field has continued to develop at a rapid rate. Increasingly elegant methods are being invented and an even wider range of possible applications is still being discovered, such that combinatorial chemistry is now an integral part of industrial and academic research. The high-class editorial team - K. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - ensure comprehensive coverage and top quality contributions. This two-volume work deals with synthetic chemistry in all its forms, applications from life sciences, chemistry and material sciences, all there is to know about compound library design and synthesis, and, of course, the general basics - making it an indispensable reference for synthetic, organic and medicinal chemists, chemical biologists as well as material scientists.
Rezensionen / Stimmen
"...an up-to-date, authoritative, comprehensive reference source that should be indispensable for synthetic, organic and medicinal chemists; chemical biologists; and material scientists." (The Chemical Educator, Vol. 10, No. 4. 2005) "...an excellent contribution to the field of research..." (Chemistry & Industry, 6 January 2003) "...this book is a valuable and rich source of information..." (Perkin Transactions, Vol.1, No.23, 2002) "...it is an excellent reference book that most researchers in the field will want on their bookshelves and/or in their library..." (Synthesis, No. 7, 2003)
Sprache
Verlagsort
Zielgruppe
Maße
Höhe: 250 mm
Breite: 130 mm
Dicke: 15 mm
Gewicht
ISBN-13
978-3-527-60303-9 (9783527603039)
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Schweitzer Klassifikation
GENERAL ASPECTS Combinatorial Chemistry in Drug Discovery Principles of Combinatorial Chemistry Solid and Soluble Supports for Heterogenous Systems Linkers for Solid Phase Synthesis Encoding Technologies Instrumentation for Combinatorial Chemistry SYNTHETIC CHEMISTRY Radical Chemistry Nucleophilic Substitution Electrophilic Substitution Elimination Addition to CC Multiple Bonds Except CC Bond Formation Addition to CX Multiple Bonds Except CO Double Bonds Chemistry of the Carbonyl Group Oxidation Except CC Double Bonds Reduction Except CC Double Bonds Cycloaddition Main Group Organometallics Enolates and Related Species Transitions Metal Catalyzed Formation of Single Bonds Metathesis and Related Processes for CC Multiple Bond Formation SPECIAL SYNTHETIC TOPICS Libraries of Natural Products Synthesis of Heterocyclic Systems Multicomponent Reactions Combinatorial Chemistry of Oligosaccharides DESIGN OF COMBINATORIAL LIBRARIES Design Criteria Estimation of Physicochemical Parameters Virtual Libraries and Modeling Case Study: Medicinal Chemistry NOVEL APPLICATIONS OF COMBINATORIAL CHEMISTRY Combinatorial Chemistry in the Fine Chemical Industry High Throughput Process Research Combinatorial Approaches to Catalyst Discovery Case Study: Combinatorial Catalyst Discovery Combinatorial Aspects of Material Research Combinatorial Principles of Biology and Their Potential Applications to Drug Discovery
