Mass Spectrometry for Drug Discovery and Drug Development

PREFACE Walter A. Korfmacher CONTRIBUTORS 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1 Gerard Hopfgartner 2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications William Bart Emary and Nanyan Rena Zhang 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment Mohammed Jemal and Yuan-Qing Xia 4 Mass Spectrometry for Quantitative in Vitro ADME Assays Jun Zhang and Wilson Z. Shou 5 Metabolite Identification Using Mass Spectrometry in Drug Development Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash 6 MS Analysis of Biological Drugs, Proteins and Peptides Yi Du, John Mehl and Pavlo Pristatsky 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics Hui Wei, Guodong Chen and Adrienne A. Tymiak 8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling Dan Eikel and Jack Henion 9 MS Applications in Support of Medicinal Chemistry Sciences Maarten Honing, Benno Ingelse and Birendra N. Pramanik 10 Imaging Mass Spectrometry of Proteins and Peptides Michelle L. Reyzer and Richard M. Caprioli 11 Imaging Mass Spectrometry for Drugs and Metabolites Stacey R. Oppenheimer 12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools Shuguang Ma and Swapan K. Chowdhury 13 Mass Spectrometry of siRNA Mark Cancilla and Mike Flanagan 14 Mass Spectrometry for Metabolomics Petia Shipkova and Michael D. Reily 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan? Lieve Dillen and Filip Cuyckens Index