A. General.- 1. Clinical relevance.- 2. Renal handling of drugs and xenobiotics.- 3. Immunologically-mediated toxin-induced renal diseases.- 4. Cellular mechanisms of nephrotoxity.- 5. Experimental models.- B. Specific Drugs.- Introduction: Anti-infectious agents.- 6. Aminoglycosides and vancomycin.- 7. The renal toxicity of beta-lactam antibiotics: Mechanisms and clinical implications.- 8. Amphotericin B.- 9. Miscellaneous drugs with nephrotoxic potential.- 10. Antiviral agents.- Introduction: Analgesic related renal injury.- 11. Analgesics.- 12. Nonsteroidal anti-inflammatory drugs: Effects on kidney function.- 13. 5-Aminosalicyclic acid and chronic interstitial nephritis.- 14. Nephrotoxicity of gold salts, D-penicillamine, and allopurinol.- 15. Renal injury from angiotensin I converting enzyme inhibitors.- 16. Diuretics.- 17. Anticancer: Cisplatin/carboplatin.- Introduction: Immunosuppressive drugs.- 18. Cyclosporine/tacrolimus (FK-506).- 19. OKT3 Nephrotoxicity: From acute tubular necrosis to hemolytic uremic syndrome.- 20. Cytokine associated renal dysfunction: Interleukins and interferons.- 21. Contrast associated nephropathy: Presentation, pathophysiology and management.- Introduction: Environmental nephrotoxins.- 22. Lead nephropathy.- 23. Cadmium-induced renal effects in the general environment.- 24. Mercury.- 25. Role of environmental/occupational exposure to organic solvents, silicon-containing compounds and pesticides in the development and progression of renal disease.- 26. Lithium and the kidney.- 27. Renal disease associated with illicit drug abuse.- 28. Renal toxicity of anesthetic agents.- 29. Nephrotoxicity of herbal remedies and trace elements used as food additives.- 30. Balkan nephropathy.- C. Prevention.- 31. Urinary biomarkers and nephrotoxicity.-32. Principles of drug dosing in renal failure.- 33. Practical dosing.
