NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

NPY family of peptides in neurobiology, cardiovascular system and metabolism: genes, diseases and therapeutics.- NPY family of peptides, receptors and processing enzymes.- An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization.- Molecular ligand-receptor interaction of the NPY/PP peptide family.- Physiological and pathophysiological perspectives of the NPY family of peptides.- Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions.- NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function.- Neuropeptide Y and sympathetic control of vascular tone in hypertension.- Neuropeptide Y and the cerebral circulation.- Neuropeptide Y and the heart: implication for myocardial infarction and heart failure.- Role of neuropeptide Y in the regulation of kidney function.- NPY and neuron-adipocyte interactions in the regulation of metabolism.- NPY and energy homeostasis: an opportunity for novel anti-obesity therapies.- Subjugation of hypothalamic NPY and cohorts with central leptin gene therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time.- NPY and bone.- NPY in alcoholism and psychiatric disorders.- Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis.- NPY and extreme stress: lessons learned from posttraumatic stress disorder.- NPY and chronic neurodegenerative disease.- Genetics of the NPY family of peptides and their receptors.- Human NPY gene variants in cardiovascular and metabolic diseases.- Summary.- Future directions and perspectives for therapies based on the NPY family of peptides.