Privileged Chiral Ligands and Catalysts

Preface
BINAP
Introduction: Structural Consideration
Hydrogenation of Olefins
Hydrogenation of Ketones
Isomerization of Allylamines and Allylalcohols
Hydroboration, Hydrosilylation, Hydroacylation, and Hydroamination
Allylic Alkylation
Heck Reaction
Aldol and Mannich-Type Reactions
Nucleophilic Additions to Carbonyl and Imino Compounds
Alpha-Substitution Reactions of Carbonyl Compounds
Michael-Type Reactions
Conjugate Additions Using Organoboron and Grignard Reagents
Diels-Alder Reaction
Ene Reaction
Cyclization
Ring-Opening Reactions
Concluding Remarks

BISPHOSPHACYCLES - FROM DuPHOS AND BPE TO A DIVERSE SET OF BROADLY APPLIED LIGANDS
Introduction
Development of Bisphosphacycle Ligands
Applications of Bisphosphacycle Ligands
Concluding Remarks

JOSIPHOS LIGANDS: FROM DISCOVERY TO TECHNICAL APPLICATIONS
Introduction and Background
Discovery and Development of the Josiphos Ligand Family
Why Are Josiphos Ligands So Effective?
Catalytic Profile of the Josiphos Ligand Family
Concluding Remarks

CHIRAL SPIRO LIGANDS
Introduction
Preparation of Chiral Spiro Ligands
Asymmetric Hydrogenation
Asymmetric Carbon-Carbon Bond Forming Reaction
Asymmetric Carbon-Heteroatom Bond Forming Reaction
Conclusion

CHIRAL BISOXAZOLINE LIGANDS
Introduction
Enantioselective Carbon-Carbon Bond Formation
Enantioselective Carbon-Heteroatom Bond Formation
Enantioselective Cycloaddition Reactions
Conclusions

PHOX LIGANDS
Introduction
Synthesis of PHOX Ligands
Nucleophilic Allylic Substitution
Decarboxylative Tsuji Allylations
Heck Reaction
Hydrogenation
Cycloadditions
Miscellaneous Reactions
Conclusion

CHIRAL SALEN COMPLEXES
Introduction
Synthesis of Chiral Salen Complexes
Structural Properties of Chiral Salen Complexes
Asymmetric Reactions Catalyzed by Chiral Salen Complexes
Conclusion and Outlook

BINOL
Introduction
Applications in Reduction and Oxidation
Metal/BINOL Chiral Lewis Acid Catalysts in Asymmetric C-C Bond Forming Reactions
Acid/Base Bifunctional Metal/BINOL Catalysts
BINOL in Organocatalysis
Summary

TADDOLATE LIGANDS
Introduction
Nucleophilic Additions to C=O Double Bonds
Nucleophilic Conjugate Additions to Electron-Deficient C=C Double Bonds
Nucleophilic Substitutions
Cycloaddition Reactions
Oxidation and Reduction Reactions
Miscellaneous Reactions
Conclusions

CINCHONA ALKALOIDS
Introduction
Metal Catalysis
Phase-Transfer Catalysis
Nucleophilic Catalysis
Base Catalysis
Cooperative and Multifunctional Catalysis
Conclusion

PROLINE DERIVATIVES
Introduction
Proline as Organocatalyst
Proline Analogs as Organocatalysts
5-Pyrrolidin-2-yltetrazole as Organocatalyst
Pyrrolidine-Based Sulfonamides as Organocatalysts
Pyrrolidine-Based Amides as Organocatalysts
Pyrrolidine Diamine Catalysts
Diarylprolinols or Diarylprolinol Ether Catalysts
Concluding Remarks