Cancer Screening and Genetics, An Issue of Surgical Clinics
1. Auflage
Erschienen am 3. September 2015
100 Seiten
978-0-323-40107-4 (ISBN)
Beschreibung
Cancer Screening and Genetics is reviewed extensively in this important Surgical Clinics of North America issue. Articles include: Cancer Genetics and Implications for Clinical Management; Epigenetics and Cancer; Screening and Early Detection of Cancer: Successes and Failures; Screening for Lung Cancer; Screening for Breast Cancer; Viral Hepatitis and Hepatocellular Cancer: How Should Patients Be Screened?; Screening for Pancreatic Cancer: Where Do We Stand?; Hereditary Colorectal Cancer: Genetics and Screening; Personalized Approach to Gastrointestinal Cancers; Screening for Colorectal Cancer; Screening for Prostate Cancer: Why the Controversy?; Gastric Cancer: East versus West-Is screening and early detection the difference?; and more!
Weitere Details
Weitere Ausgaben
Inhalt
- Front Cover
- Cancer Screeningand Genetics
- Copyright
- Contributors
- CONSULTING EDITOR
- EDITOR
- AUTHORS
- Contents
- Foreword: Cancer Screening and Genomics
- Preface
- Background
- Cancer Genetics and Implications for Clinical Management
- The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure
- Principles of Cancer Screening
- Screening and Early Detection: Specific Diseases
- Lung Cancer Screening
- Colorectal Cancer Screening
- Breast Cancer Screening
- Screening for Viral Hepatitis and Hepatocellular Cancer
- Prostate Cancer Screening and the Associated Controversy
- Screening for Pancreatic Cancer
- Screening and Early Detection of Gastric Cancer: East Versus West
- Hereditary Colorectal Cancer: Genetics and Screening
- Personalized Approaches to Gastrointestinal Cancers: Importance of Integrating Genomic Information to Guide Therapy
- SURGICAL CLINICS OF NORTH AMERICA
- FORTHCOMING ISSUES
- December 2015
- February 2016
- April 2016
- RECENT ISSUES
- August 2015
- June 2015
- April 2015
- February 2015
- Foreword
- Preface
- Cancer Genetics and Implications for Clinical Management
- Key points
- INTRODUCTION
- UNDERSTANDING THE CANCER GENOME LANDSCAPE AND TRANSLATING ADVANCES FOR THERAPEUTIC GAIN
- DRIVER VERSUS PASSENGER MUTATIONS
- MUTATIONAL SIGNATURES IN CANCER
- RATIONALE OF GENOTYPE-GUIDED MEDICINE
- MANAGING TUMOR HETEROGENEITY AND RESISTANCE TO TARGETED THERAPY
- ADVANCING MOLECULAR PHENOTYPE-GUIDED THERAPY IN PANCREATIC CANCER
- INDIVIDUALIZED THERAPY INITIATIVES
- INHERITED SUSCEPTIBILITY OF CANCER IN THE ERA OF NEXT-GENERATION SEQUENCING
- EXCEPTIONAL RESPONDERS
- SUMMARY
- REFERENCES
- The Triple-Code Model for Pancreatic Cancer
- Key points
- CROSS TALK BETWEEN GENETICS AND EPIGENETICS AS A PROMISING PARADIGM IN PANCREATOLOGY
- MECHANISTIC BASIS OF EPIGENETICS: THE NUCLEOSOME
- Sequence Specific Transcription Factors Function as Adaptor Proteins to Link DNA to Epigenetic Regulators
- Nucleosome Remodeling Machines and Histone-Modifying Enzymes Work in Concert to Regulate Histone Marks
- MARKING THE GENOME BY METHYLATION
- EPIGENETIC REGULATION BY NONCODING RNAS
- SHAPING GENE EXPRESSION THROUGH NUCLEAR ARCHITECTURE
- EPIGENETICS OPENS A NEW ERA FOR PANCREATIC CANCER MARKERS AND NOVEL THERAPEUTIC MODALITIES
- SUMMARY
- REFERENCES
- Principles of Cancer Screening
- Key points
- INTRODUCTION
- PERFORMANCE CHARACTERISTICS OF SCREENING TESTS
- MEASURES OF SCREENING BENEFIT
- Population Measures
- COMMON BIASES IN ASSESSING THE BENEFITS OF SCREENING
- HARMS OF SCREENING
- Overdiagnosis
- COST-EFFECTIVENESS AND TARGETED SCREENING
- Targeted Screening
- CURRENT RECOMMENDED CANCER SCREENING TESTS IN NORTH AMERICA
- REFERENCES
- Lung Cancer Screening
- Key points
- INTRODUCTION
- RISKS AND HARMS OF LUNG CANCER SCREENING
- Radiation
- Invasive Procedures
- Anxiety and Stress
- Overdiagnosis
- Estimates of the Rate of Overdiagnosis in Lung Cancer Screening
- PRACTICE OF LUNG CANCER SCREENING
- Multidisciplinary Lung Cancer Screening Program
- Eligibility for Lung Cancer Screening
- Computed Tomography Protocol
- Definition of Abnormal Results on Low-Dose Computed Tomography
- Reporting and Communication
- Evaluation of Abnormal Findings
- Smoking Cessation
- Education
- SUMMARY
- REFERENCES
- Colorectal Cancer Screening
- Key points
- INTRODUCTION: EXTENT OF THE DISEASE
- Risk Factors
- SCREENING TECHNIQUES AND OPTIONS
- Early Detection Versus Prevention
- Stool Tests for Colorectal Cancer Screening
- Guaiac-based fecal occult blood test
- Fecal immunochemical test
- Stool DNA tests
- Structural Examinations of the Colon and Rectum
- Flexible sigmoidoscopy
- Colonoscopy
- Computed tomographic colonography
- Capsule colonoscopy
- Double-contrast barium enema
- Programmatic Versus Opportunistic Screening
- Colorectal Cancer Screening Guidelines
- CLINICAL OUTCOMES
- Ongoing Research
- COMPLICATIONS AND CONCERNS
- SUMMARY
- REFERENCES
- Breast Cancer Screening
- Key points
- INTRODUCTION
- Population Screening
- Screening Mammography Recommendations
- The Breast Cancer Screening Controversy
- SCREENING TECHNIQUES AND OPTIONS
- Clinical Breast Examination and Breast Self-examination
- Mammography
- Breast MRI
- Screening Sonography
- Gamma-Emitting Radioisotope Imaging
- Other Modalities
- PERSONALIZED BREAST CANCER SCREENING
- Mammographic Density
- Enhanced Surveillance in Increased Risk Populations
- COMPLICATIONS AND CONCERNS
- SUMMARY
- REFERENCES
- Screening for Viral Hepatitis and Hepatocellular Cancer
- Key points
- SCREENING FOR HEPATITIS B VIRUS INFECTION
- SCREENING FOR HEPATITIS C VIRUS INFECTION
- DIAGNOSING OTHER VIRAL HEPATITIDES
- Hepatitis A
- Hepatitis D
- Hepatitis E
- Cytomegalovirus
- Epstein-Barr Virus
- Herpes Simplex Virus
- Varicella Zoster Virus
- SCREENING FOR HEPATOCELLULAR CARCINOMA
- WHEN TO OBTAIN A LIVER BIOPSY TO DIAGNOSE HEPATOCELLULAR CARCINOMA
- REFERENCES
- Prostate Cancer Screening and the Associated Controversy
- Key points
- INTRODUCTION
- Extent of Disease
- Natural History of Prostate Cancer
- Risk Factors
- SCREENING TECHNIQUES AND OPTIONS
- Prostate-Specific Antigen
- Impact of Prostate-Specific Antigen Screening on the Epidemiology of Prostate Cancer
- Limitations of Prostate-Specific Antigen
- CLINICAL OUTCOMES
- Prostate Cancer Screening Trials: Prostate, Lung, Colorectal, and Ovarian and European Randomized Study of Screening for Pr ...
- US Preventive Services Task Force 2012 Recommendation
- COMPLICATIONS AND CONCERNS
- Critique of the US Preventive Services Task Force Recommendation
- Impact of the US Preventive Services Task Force Recommendation
- Addressing the Concerns: Strategies to Prevent Overdiagnosis and Overtreatment
- Professional Organizations' Recommendations
- Future Directions
- SUMMARY
- REFERENCES
- Screening for Pancreatic Cancer
- Key points
- INTRODUCTION
- HOW EARLY DOES PANCREATIC CANCER HAVE TO BE DETECTED FOR CURE?
- TARGET LESIONS
- WHO IS AT RISK OF DEVELOPING PANCREATIC CANCER? WHO SHOULD BE SCREENED?
- How Should Individuals at Risk Be Screened?
- HOW SHOULD SUSPECTED LESIONS BE MANAGED?
- REFERENCES
- Screening and Early Detection of Gastric Cancer
- Key points
- GASTRIC CANCER EPIDEMIOLOGY: MORTALITY, INCIDENCE BETWEEN EAST AND WEST
- RISK FACTORS
- Helicobacter pylori
- Diet and Smoking
- GASTRIC CANCER SCREENING EFFECT: EARLY DETECTION AND THE ASIAN EXPERIENCE
- Korea
- Japan
- Taiwan
- West
- DIFFERENCE OF TREATMENT STRATEGY
- GENETIC DISPARITY
- SUMMARY
- REFERENCES
- Hereditary Colorectal Cancer
- Key points
- INTRODUCTION
- LYNCH SYNDROME
- Clinical Features
- Genetic Defect
- Genetic Testing
- Management
- FAMILIAL ADENOMATOUS POLYPOSIS
- Clinical Features
- Genetic Defect
- Management
- Colorectum
- Upper gastrointestinal tract
- Desmoid tumors
- MUTYH-ASSOCIATED POLYPOSIS
- Clinical Features
- Genetic Defect
- Management
- SUMMARY
- ACKNOWLEDGMENTS
- REFERENCES
- Personalized Approaches to Gastrointestinal Cancers
- Key points
- INTRODUCTION
- Tumor Heterogeneity
- CURRENT CONCERNS AND LIMITATIONS OF DIAGNOSIS AND THERAPY
- PERSONALIZED TREATMENT OF PANCREATIC CANCERS
- PERSONALIZED TREATMENT OF GASTROINTESTINAL STROMAL TUMORS
- PERSONALIZED TREATMENT IN COLORECTAL CANCER
- PERSONALIZED TREATMENT IN GASTRIC CANCER
- PROGNOSIS
- Oncotype DX
- ColoPrint
- Circulating Tumor Cells
- SUMMARY
- REFERENCES
- Index
