Analysis of Complex Diseases
A Mathematical Perspective
Erschienen am 18. Dezember 2013
222 Seiten
978-1-040-18917-7 (ISBN)
Beschreibung
A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize trea
Weitere Details
Sprache
Englisch
Verlagsort
London
Großbritannien
Verlagsgruppe
Taylor & Francis Ltd
Zielgruppe
Für Beruf und Forschung
Für höhere Schule und Studium
Dateigröße
4,32 MB
ISBN-13
978-1-040-18917-7 (9781040189177)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
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Person
Guanyu Wang obtained one PhD (in engineering) from Zhejiang University, China, in 1998 and one PhD (in medical sciences) from the University of Cologne, Germany, in 2005. As a postdoctoral fellow, he was initially at the School of Health Information of the University of Texas Health Science Center at Houston and then at the Department of Bioengineering, Rice University. He was an assistant professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston and then an assistant professor of Physics at George Washington University. He is now an associate professor of biology at South University of Science and Technology of China, located in the city of Shenzhen.
Inhalt
Organismal Level: What Is Required. Food Intake and Energy Metabolism. Glucose Homeostasis. Optimal Glucose Homeostasis. Bistability as a Fundamental Phenomenon. Molecular Level: What Can Be Provided? Molecular Biology. Biomolecular Network. PI3K-AKT-TOR Pathway. Mathematical Analysis of Complex Diseases. Diseases Related to Metabolism. Mathematical Modeling of the PI3K-AKT-TOR Pathway. Fundamental Decomposition. Normal Phenotype. Disease Phenotypes. Tao of Diseases. References. Abbreviations. Appendix A Optimization of Insulin Action. Appendix B Derivation of the Master Equation of AKT Activation. Appendix C Singularity Theory. Appendix D Analysis of the Simplified Master Equation. Appendix E Analysis of the Master Equation. Index.
