Neopterin
Biochemistry - Methods - Clinical Application
1. Auflage
Erschienen am 1. Juni 2011
XIII, 294 Seiten
978-3-11-085278-3 (ISBN)
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01/1992
1. Auflage
De Gruyter
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Inhalt
- Intro
- 1 Pteridines
- 1.1 Historical remarks
- 1.2 Occurrence
- 1.3 Biosynthesis
- 1.4 Biochemical functions
- References
- 2 Neopterin
- 2.1 Chemical characteristics
- 2.2 Catabolism
- 2.3 Biochemical and physiological relevance
- References
- 3 Measurement of Neopterin
- 3.1 Historical remarks
- 3.2 Measurement by reversed phase HPLC without pretreatment of samples
- 3.3 Measurement of neopterin by reversed phase HPLC with on-line deproteinization
- 3.4 Measurement of neopterin by immunoassays
- References
- 4 Normal Ranges of Neopterin Concentrations in Various Body Fluids
- 4.1 Normal ranges of neopterin concentrations in urine
- 4.2 Normal ranges of neopterin concentrations in serum
- 4.3 Normal ranges of neopterin concentrations in cerebrospinal fluid
- 4.4 Normal ranges of neopterin concentrations in synovial fluid
- 4.5 Normal ranges of neopterin concentrations in saliva
- 4.6 Discussion
- References
- 5 Biosynthesis of Pteridines and the Human Immune System
- 5.1 Immunological activation and cytokines
- 5.2 Cytokines and pteridine biosynthesis
- 5.3 Inducers of pteridine synthesis in human cells
- 5.4 Cell culture techniques
- 5.5 Determination of pteridines in cell homogenates and supernatants
- 5.6 Enzyme activities of pteridine synthesis in cell extracts
- 5.7 Biological significance of cytokine-induced pteridine synthesis
- References
- 6 Neopterin in Organ Transplantation
- 6.1 Renal transplantation
- 6.2 Transplantation of solid organs other than kidney
- 6.3 Transplantation of bone marrow
- References
- 7 Neopterin in Autoimmune Diseases and Related Inflammatory Disorders
- 7.1 Neopterin in rheumatoid arthritis
- 7.2 Neopterin in inflammatory bowel diseases
- 7.3 Neopterin in autoimmune diabetes
- 7.4 Neopterin in autoimmune diseases of the thyroid
- 7.5 Neopterin in systemic lupus erythematosus
- 7.6 Neopterin in multiple sclerosis
- 7.7 Neopterin in sarcoidosis
- 7.8 Neopterin in celiac disease
- References
- 8 Neopterin in Malignant Diseases
- 8.1 Hematological malignancies
- 8.2 Gynecological malignancies
- 8.3 Malignancies of the urogenital tract
- 8.4 Lung cancer
- 8.5 Gastrointestinal, pancreatic and hepatic cancer
- 8.6 Breast cancer
- 8.7 Cancers of the head and neck region
- 8.8 Malignant melanoma
- 8.9 Neopterin in malignant diseases - a summary
- References
- 9 Neopterin in Infectious Diseases
- 9.1 Infections by viruses
- 9.2 Neopterin during infection by human immunodeficiency virus type 1 (HIV-1) and the acquired immunodeficiency syndrome (AIDS)
- 9.3 Infections by intracellular protozoa
- 9.4 Infections by bacteria
- 9.5 Neopterin during sepsis and trauma
- References
- 10 Monitoring of Immunostimulatory Therapy
- References
- 11 Neopterin in Transfusion Medicine
- References
- Appendix
- References
- Subject Index
