Separation Methods in Drug Synthesis and Purification

PrefaceKlara Valko 1. Comparison of various modes and phase systems for analytical HPLC Pavel Jandera 2. Fast-generic HPLC methods Ian M. Mutton 3. Advances in capillary electrochromatography José Luís Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink 4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial libraries Steve Lane 5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations J. Viaene and Y. Vander Heyden 6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLab Halina Katsialevich, Hans-Jürgen Rieger, Imre Molnár and Arnold Zöldhegyi 7. The flexible application of automated preparative purification platforms within drug discovery Jennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin 8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry Drew Katti 9. Recent developments in liquid and supercritical fluid chromatographic enantioseparations Debby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden 10. Basis and pharmaceutical applications of thin-layer chromatography Huba Kalász, Mária Báthori and Klára Valko 11. Recent advances in quantitative structureeretention relationships Roman Kaliszan 12. Capillary electrophoresis for drug analysis and physicochemical characterization Susana Amézqueta, Xavier Subirats, Elisabet Fuguet, Clara Ràfols and Martí Rosés 13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery Klára L. Valkó