Copper-Containing Molecules

Name: Copper-Containing Molecules
Brand: Academic Press
Price: 137.0 EUR
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Joan S. Valentine(Autor*in)

Joan S. Valentine Edith B. Gralla(Herausgeber*in)

Academic Press

Erschienen am 28. Mai 2014

505 Seiten

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978-0-08-054406-9 (ISBN)

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Front Cover
Copper-Containing Proteins
Copyright Page
Contents
Preface
Chapter 1. Galactose Oxidase
I. Introduction
II. Protein Structure
III. Sequence Correlations
IV. The Metal-Binding Site
V. Spectroscopic Probes of Metal Interactions
VI. Probes of the Radical Site
VII. The Free Radical-Coupled Copper Active Site
VIII. Catalytic Mechanism
IX. Cofactor Biogenesis
X. Biomimetic Model Studies
XI. Biomedical Applications
XII. Summary and Conclusions
References
Chapter 2. Copper Metalloregulation of Gene Expression
I. Copper Homeostasis
II. Copper Metalloregulation in Prokaryotes
III. Copper Metalloregulation in Eukaryotes
IV. Copper-Induced Transcription in Animal Cells
V. Summary of Mechanism of Copper-Modulated Transcription
References
Chapter 3. Bacterial Copper Transport
I. Introduction
II. The New Subclass of Heavy Metal CPx-type ATPases
III. Copper Homeostasis in Enterococcus hirae
IV. Copper Resistance in Escherichia coli
V. Other Bacterial Copper ATPases
VI. Mechanism of Copper ATPases
VII. Other Copper-Resistance Systems
VIII. Conclusions
References
Chapter 4. Understanding the Mechanism and Function of Copper P-type ATPases
I. Introduction
II. Heavy Metal Toxicity and Essentiality
III. Vectorial Copper Transport
IV. P-type ATPases
V. Heavy Metal P-type ATPases
VI. Conclusion
References
Chapter 5. Copper Chaperones
I. Introduction
II. Copper Chaperones of the Atxl-like Family
III. Copper Chaperones for Copper-Zinc Superoxide Dismutase
IV. Copper Chaperones for Cytochrome c Oxidase
V. Conclusions
References
Chapter 6. Fet3p, Ceruloplasmin, and the Role of Copper in Iron Metabolism
I. Copper Pumps, Ferroxidases, and Iron Homeostasis in Eukaryotes
II. Biologic Copper Sites and the Multicopper Oxidases
III. The Ferroxidases
IV. Fet3p and Ftrlp in Iron Updake in Saccharomyces cerevisiae: The Molecular Link between Copper and Iron Metabolism
V. Ferroxidase Structure: hCp and Fet3p
VI. Ferroxidase Reaction
VII. Convergence of Structural and Cell Biology in Iron Metabolism
References
Chapter 7. Blue Copper-Binding Domains
I. lntroduction
II. Four Classes of BCB Domain-Containing Proteins
III. Folding Topology of the BCB Domains and Spectroscopic and Structural Properties of the Blue Copper Sites
IV. Cupredoxins
V. Phytocyanins
VI. Ephrins
VII. Multicopper Oxidases
VIII. Coagulation Factors V and VIII
IX. BCB Domains with a Binuclear CuA Site
X. Nitrosocyanin
References
Chapter 8. Cytochrome c Oxidase
I. lntroduction
II. Purification and Crystallization
III. Composition of Bovine Heart Cytochrome c Oxidase
IV. X-Ray Structures of Cytochrome c Oxidase
V. Functions of the Redox-Active Metal Sites in This Enzyme
VI. Proton Transfer Mechanism
References
Chapter 9. Nuclear Magnetic Resonance Spectroscopy Studies on Copper Proteins
I. Introduction
II. The Influence of the Copper Ion on the NMR Spectra
III. Additional NMR Tools
IV. NMR Studies on Mononuclear Type I Copper Proteins
V. NMR Studies on Mononuclear Type II Copper-Containing Proteins
VI. NMR Studies of Proteins Containing Polynuclear Copper Centers
VII. Other Copper-Binding Proteins
VIII. Perspectives
References
Author Index
Subject Index

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