Eclampsia: Prevalence, Risk Factors and Complications
Erschienen am 3. Mai 2021
134 Seiten
978-1-5361-9674-0 (ISBN)
Beschreibung
This book is composed of three chapters about eclampsia, which is a condition involving seizures that occur during a woman's pregnancy or shortly after giving birth. Chapter One analyses the clinical profile, neurological manifestations, imaging features, prognosis and risk factors which can predict neurological complications in eclampsia patients. Chapter Two describes the discovery of phosphoester steroid conjugates and proposes a role for them in pre-eclampsia. Chapter Three discusses postpartum eclampsia and describes which medications should be used for management of symptoms in patients who show signs of pre-eclampsia.
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05/2021
Nova Science Publishers Inc
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Inhalt
- Intro
- Contents
- Preface
- Chapter 1
- Neurological Complications of Eclampsia
- Abstract
- Objectives
- Methodology
- Results
- Conclusion
- Introduction
- Methodology
- Statistical Analysis
- Result
- Demographic and Obstetrical Characteristics (Table 1)
- Neurological Manifestations in Eclamptic Patients (Table 2)
- Fundus Changes (Table 3)
- Neuro Imaging Findings (Table 4)
- Neurological Sequelae in Relation to Pathology in the Antenatal Period (Figure 6)
- Day of Manifestation of Neurological Complications in the Postpartum Period (Figure 7)
- Risk Factor Analysis (Table 5)
- Independent Risk Factor Analysis (Table 7)
- Determinants of Arterial Infarcts in Eclampsia Patients (Table 8)
- Determinants of ICH in Eclampsia Patients (Table 9)
- Determinants of CVT in Eclampsia Patients (Table 10)
- Visual Complications in Eclampsia
- Retinal Detachment
- Prognosis
- Discussion
- Haemodynamic in Normal Pregnancy
- Cerebrovascular Changes in Pre-Eclampsia/Eclampsia
- Pathogenesis of Cerebral Oedema
- Causes of Neurological Deficits and Blindness in Eclampsia
- Arterial Ischemic Stroke
- Stroke due to Intracerebral Haemorrhage
- Stroke due to Cerebral Venous Thrombosis (CVT)
- Posterior Reversible Encephalopathy Syndrome (PRES)
- Visual Disturbances
- Diagnosis
- Management
- Prognosis
- Long Term Consequences
- Prevention
- Conclusion
- Acknowledgments
- Disclosure
- References
- Chapter 2
- Pre-Eclampsia: It's All About Potassium
- Abstract
- 1. Introduction
- 1.1. Discovery
- 1.2. Function of Ionotropin
- 1.3. Regulatory Background
- 1.4. Pilot Study
- 1.5. Theory
- 2. Discovery of Cardiotonic Steroids
- 2.1. First Candidate
- 2.2. Our Candidate
- 2.3. Nomenclature of Spiral Steroids
- 2.4. Isolation of Spiral Steroids
- 2.4.1. Extraction
- 2.4.2. Isolation from Human Breast Cyst Fluids
- 2.4.3. Isolation from Bovine and Porcine Serum
- 2.4.4. Model Compound: DHEA-Phosphocholine Ester
- 2.5. NMR Analysis of the Steroids with 23 Carbon Atoms
- 2.5.1. 31P-NMR Analysis of the Steroids with 23 Carbon Atoms
- 2.5.2. 13C NMR Analysis of the Steroids with 23 Carbon Atoms
- 2.6. Trial-and-Error Determination of Composition
- 2.6.1. Composition of C313
- 2.6.2. Composition of C341 (Ionotropin)
- 2.6.3. Biosynthesis of Spiral Steroids
- 2.6.4. Formation of Phosphoesters
- 2.7. Steroid Phosphoesters in Non-Mammalian Species
- 2.8. Summary
- 3. Function of Spiral Steroids (Ionotropin)
- 3.1. Background
- 3.2. Why Do We Need Potassium Sparing Hormones?
- 3.3. Structural Features of Potassium Sparing Diuretics
- 3.4. Do Spiral Steroids Have Nuclear Receptors?
- 3.5. SLO Syndrome - Spiral Steroid Deficiency
- 3.6. Human Breast Cyst Fluids
- 3.7. Summary
- 4. Phosphosteroids during Pregnancy
- 4.1. Background
- 4.2. Concept: Role of Spiral Steroids
- 4.2.1. Human Cord Serum Investigations
- 4.2.2. Infants Postpartum
- 4.3. Pre-Eclampsia - Syndrome or Disease?
- 4.4. Pre-Eclampsia and Spiral Steroids
- 4.4.1. Pilot Study
- 4.4.2. Method of Analysis
- 4.4.3. Normotensive & Pre-Eclampsia Mass Spectra
- 4.4.4. Identification of the Ions in Serum from Pregnant Women
- 4.4.5. Pilot Study - Z-Scores
- 4.4.6. Comparison of Elevated Precursor Levels to Other Proposed Markers for Pre-Eclampsia
- 4.5. Pathophysiology of Pre-Eclampsia as a Disease
- 4.6. Summary - Spiral Steroids vs Cardiotonic Glycosides
- 4.7. Proposed Clinical Application
- 5. Pre-Eclampsia and Life-Threatening Hypertension
- Conclusion
- Acknowledgments
- Funding Statement
- References
- Chapter 3
- Postpartum Pre-Eclampsia
- Abstract
- References
- Index
- Blank Page
- Blank Page
