Cancer as a Metabolic Disease
On the Origin, Management, and Prevention of Cancer
Erschienen am 14. Mai 2012
438 Seiten
978-1-118-31029-8 (ISBN)
Beschreibung
The book addresses controversies related to the origins of cancerand provides solutions to cancer management and prevention. Itexpands upon Otto Warburg's well-known theory that all cancer is adisease of energy metabolism. However, Warburg did not linkhis theory to the "hallmarks of cancer" and thus his theory wasdiscredited. This book aims to provide evidence, throughcase studies, that cancer is primarily a metabolic diseaserequring metabolic solutions for its management andprevention. Support for this position is derived fromcritical assessment of current cancer theories. Brain cancercase studies are presented as a proof of principle for metabolicsolutions to disease management, but similarities are drawn toother types of cancer, including breast and colon, due tothe same cellular mutations that they demonstrate.
Rezensionen / Stimmen
"This book offers a refreshing perspective for anyonewanting to get a comprehensive background on the newer emerginginterest in targeting cancer metabolism for therapy." (Doody's, 11 January 2013) "For the first time, an entire issue is being devoted to areview article based on a recent medical book. This is a departurefrom our usual format, but I think you will agree that this topicwarrants the detailed treatment we have given it . . .This bookshould be required reading for all scientifically literate peoplewho are involved in the cancer problem." (Advancesin Cancer Treatment, 1 October 2012)Weitere Details
Weitere Ausgaben
Person
THOMAS N. SEYFRIED, PhD, has taught and conductedresearch in the fields of neurogenetics, neurochemistry, and cancerfor more than twenty-five years at Yale University and BostonCollege. He has published more than 150 scientific articles andbook chapters and is on the editorial boards of Nutrition &Metabolism, Journal of Lipid Research, Neurochemical Research,and ASN Neuro.
Inhalt
Chapter 1. Images of Cancer
Chapter 2. Confusion surrounds the origin of cancer
Chapter 3. Cancer Models
Chapter 4. Energetics of normal cells and cancer cells
Chapter 5. Respiratory Dysfunction in Cancer Cells
Chapter 6. The Warburg Dispute
Chapter 7. Is Respiration Normal in Most Cancer Cells?
Chapter 8. Is Mitochondrial Glutamine Fermentation the Missing Link in the Metabolic Theory of Cancer?
Chapter 9. Genes, Respiration, Viruses, Cancer
Chapter 10. Respiratory Injury, the retrograde response, and the origin of cancer
Chapter 11. Mitochondria: The ultimate tumor suppressor
Chapter 12. Linking Abnormalities in Growth Control, Telomerase Activity
Chapter 13. Metastasis
Chapter 14. Mitochrondrial Respiratory Dysfunction and the Extrachromosomal Origin of Cancer
Chapter 15. Nothing in Cancer Biology Makes Sense Except in the Light of Evolution
Chapter 16. Cancer Treatment Strategies
Chapter 17. Metabolic management of cancer
Chapter 18. Implementation of Metabolic Therapies for Cancer Management
Chapter 19. Cancer Prevention
Chapter 20. Case Studies and Personal Experiences in Using the Ketogenic Diet for Cancer Management
Chapter 21. Conclusions
