The term "natural products" spans an extremely large and diverse range of chemical compounds derived and isolated from biological sources. Our interest in natural products can be traced back thousands of years for their usefulness to humankind, and this continues to the present day. Compounds and extracts derived from the biosphere have found uses in medicine, agriculture, cosmetics, and food in ancient and modern societies around the world. Therefore, the ability to access natural products, understand their usefulness, and derive applications has been a major driving force in the field of natural product research. The first edition of Natural Products Isolation provided readers for the first time with some practical guidance in the process of extraction and isolation of natural products and was the result of Richard Cannell's unique vision and tireless efforts. Unfortunately, Richard Cannell died in 1999 soon after completing the first edition. We are indebted to him and hope this new edition pays adequate tribute to his excellent work. The first edition laid down the "ground rules" and established the techniques available at the time. Since its publication in 1998, there have been significant developments in some areas in natural product isolation. To capture these developments, publication of a second edition is long overdue, and we believe it brings the work up to date while still covering many basic techniques known to save time and effort, and capable of results equivalent to those from more recent and expensive techniques.
Rezensionen / Stimmen
". . . offers extensive help in the selection of a suitable methodology. . .an excellent aid. . .closes a painfully evident gap in the selection of monographs on natural products chemistry. . .warmly recommended to anyone interested in the isolation of natural products."-Angewandte Chemie
". . .a very good general reference that concentrates a considerable amount of useful practical information. . .well worth considering as a reference for graduate students or other researchers who might need to familiarize themselves with the intricacies of the subject."-Journal of Natural Products
"...contains a wealth of practical information, hints, and useful points...an asset in any laboratory where natural products isolation is performed." -Journal of Medicinal Chemistry
"...a very good general reference that concentrates a considerable amount of useful practical information." -Pathology
"...excellent and comprehensive...wholeheartedly recommend[ed]...as a comprehensive handbook for solving problems in daily research." -Drug Discovery Today
Reihe
Auflage
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
133
133 s/w Abbildungen
XII, 516 p. 133 illus.
ISBN-13
978-1-59259-955-4 (9781592599554)
DOI
Schweitzer Klassifikation
Natural Product Isolation.- Initial and Bulk Extraction.- Supercritical Fluid Extraction.- An Introduction to Planar Chromatography.- Isolation of Natural Products by Low-Pressure Column Chromatography.- Isolation by Ion-Exchange Methods.- Separation by High-Speed Countercurrent Chromatography.- Isolation by Preparative High-Performance Liquid Chromatography.- Hyphenated Techniques.- Purification by Solvent Extraction Using Partition Coefficient.- Crystallization in Final Stages of Purification.- Dereplication and Partial Identification of Compounds.- Extraction of Plant Secondary Metabolites.- Isolation of Marine Natural Products.- Isolation of Microbial Natural Products.- Purification of Water-Soluble Natural Products.- Scale-Up of Natural Product Isolation.- Follow-Up of Natural Product Isolation.