
Management of Medication-related Osteonecrosis of the Jaw, An Issue of Oral and Maxillofacial Clinics of North America 27-4
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Inhalt
- Front Cover
- Management of MedicationrelatedOsteonecrosis of the Jaw
- Copyright
- Contributors
- CONSULTING EDITOR
- EDITOR
- AUTHORS
- Contents
- Preface
- Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw
- Pathophysiology of Osteonecrosis of the Jaws
- Medication-Related Osteonecrosis of the Jaw: Basic and Translational Science Updates
- The Frequency of Medication-related Osteonecrosis of the Jaw and its Associated Risk Factors
- Management of Medication-Related Osteonecrosis of the Jaw
- Preventive Strategies for Patients at Risk of Medication-related Osteonecrosis of the Jaw
- Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw
- The Role of Antiangiogenic Therapy in the Development of Osteonecrosis of the Jaw
- Antiresorptive Therapies for Osteoporosis
- Antiresorptive Therapies for the Treatment of Malignant Osteolytic Bone Disease
- Indications and Outcomes of Osteoporosis and Bone Modulation Therapies
- ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
- FORTHCOMING ISSUES
- February 2016
- May 2016
- August 2016
- RECENT ISSUES
- August 2015
- May 2015
- February 2015
- Preface
- Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- NOMENCLATURE AND DIAGNOSTIC CRITERIA
- CLINICAL PRESENTATION
- IMAGING
- HISTOPATHOLOGY
- CLINICAL STAGING
- SUMMARY
- REFERENCES
- Pathophysiology of Osteonecrosis of the Jaws
- Key points
- INTRODUCTION
- PROPOSED HYPOTHESES OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW PATHOPHYSIOLOGY
- Hypothesis 1: Bone-Remodeling Inhibition
- Hypothesis 2: Inflammation and Infection
- Hypothesis 3: Angiogenesis Inhibition
- Hypothesis 4: Soft Tissue Toxicity
- Hypothesis 5: Innate or Acquired Immunity Dysfunction
- SUMMARY
- REFERENCES
- Medication-Related Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- MEDICATION-RELATED OSTEONECROSIS OF THE JAW AT THE CELL LEVEL-BISPHOSPHONATE ACTION ON CELLS AND TISSUE ACCUMULATION
- ANIMAL MODELS OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW: THE TOOLBOX IS FULL AND READY TO BE PUT TO WORK
- Rodent Models
- Large Animal Models
- WHERE DO WE GO FROM HERE?
- REFERENCES
- The Frequency of Medication-related Osteonecrosis of the Jaw and its Associated Risk Factors
- Key points
- INTRODUCTION
- Challenges of Estimating the Frequency of Uncommon Diseases
- SUMMARY OF FINDINGS
- RISK FACTORS FOR MEDICATION-RELATED OSTEONECROSIS OF THE JAWS
- Medication-related Risk Factors
- Are antiresorptive or antiangiogenic agents risk factors for osteonecrosis of the jaw?
- Risk for medication-related osteonecrosis of the jaws among patients with cancer
- Risk for medication-related osteonecrosis of the jaws among patients treated for osteoporosis
- Local Factors
- Operative treatment
- Anatomic factors
- Concomitant oral disease
- Demographic and Systemic Factors and Other Medication Factors
- Genetic Factors
- SUMMARY
- REFERENCES
- Management of Medication-Related Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- MEDICAL MANAGEMENT
- Antimicrobials
- Topical antimicrobials
- Oral antimicrobials
- Intravenous antimicrobials
- Other Medications
- Pentoxifylline and vitamin E
- Teriparatide
- Hyperbaric Oxygen Therapy
- SURGICAL MANAGEMENT
- Mandibular Resection
- Maxilla Resection
- SUMMARY
- REFERENCES
- Preventive Strategies for Patients at Risk of Medication-related Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- PATIENTS AT RISK
- Medication Related to Osteonecrosis of the Jaw
- Bisphosphonates
- Receptor activator of nuclear factor kappa-B ligand inhibitor
- Angiogenesis inhibitors
- PREVENTIVE STRATEGIES BEFORE COMMENCEMENT OF ANTIRESORPTIVES
- Dental Screening
- PREVENTIVE STRATEGIES AFTER COMMENCEMENT OF ANTIRESORPTIVES
- Dentoalveolar Surgery
- New Risk-reducing Strategies at Time of Extraction
- Implants
- Endodontics
- Periodontics
- Drug Holiday
- SUMMARY
- REFERENCES
- Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- PHARMACOGENETICS AND ADVERSE DRUG REACTIONS
- GENOME-WIDE ASSOCIATION STUDIES ON OSTEONECROSIS OF THE JAW
- CANDIDATE GENE STUDIES ON OSTEONECROSIS OF THE JAW
- Replication Candidate Gene Studies
- Discovery Candidate Gene Studies
- SUMMARY
- REFERENCES
- The Role of Antiangiogenic Therapy in the Development of Osteonecrosis of the Jaw
- Key points
- INTRODUCTION
- MEDICATION-RELATED OSTEONECROSIS OF THE JAWS IN PATIENTS RECEIVING THE VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITOR BEVACIZ ...
- MEDICATION-RELATED OSTEONECROSIS OF THE JAWS IN PATIENTS RECEIVING TYROSINE KINASE INHIBITORS, WITH AND WITHOUT ANTIRESORPT ...
- MEDICATION-RELATED OSTEONECROSIS OF THE JAWS IN PATIENTS RECEIVING MAMMALIAN TARGET OF RAPAMYCIN INHIBITORS WITH OR WITHOUT ...
- MEDICATION-RELATED OSTEONECROSIS OF THE JAWS AND IMMUNOMODULATORY AGENTS WITH AN ANTIANGIOGENIC PROFILE
- SUMMARY
- REFERENCES
- Antiresorptive Therapies for Osteoporosis
- Key points
- REFERENCES
- Antiresorptive Therapies for the Treatment of Malignant Osteolytic Bone Disease
- Key points
- INTRODUCTION
- PAMIDRONATE
- ZOLEDRONIC ACID (ZOLEDRONATE)
- DENOSUMAB
- SUMMARY
- REFERENCES
- Indications and Outcomes of Osteoporosis and Bone Modulation Therapies
- Key points
- REFERENCES
- Index
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