Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America

Name: Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America
Brand: Elsevier
Price: 86.99 EUR
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Mark W. Onaitis Thomas A. D'Amico(Autor*in)

Elsevier (Verlag)

1. Auflage

Erschienen am 19. Januar 2016

100 Seiten

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978-0-323-41717-4 (ISBN)

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Front Cover
Pulmonary Metastasectomy
Copyright
Contributors
CONSULTING EDITOR
EDITORS
AUTHORS
Contents
Preface: Modern Management of Pulmonary Metastases
The Biology of Pulmonary Metastasis
Preoperative Evaluation and Indications for Pulmonary Metastasectomy
Open Surgical Approaches for Pulmonary Metastasectomy
Ablative Approaches for Pulmonary Metastases
Lymphadenectomy During Pulmonary Metastasectomy
Results of Pulmonary Resection: Colorectal Carcinoma
Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors
Isolated Lung Perfusion for Pulmonary Metastases
Immunotherapy for Resected Pulmonary Metastases
Is Surgery Warranted for Oligometastatic Disease?
Thoracoscopic Management of Pulmonary Metastases
Results of Pulmonary Resection: Other Epithelial Malignancies
Thoracoscopic Lung Suffusion
THORACIC SURGERY CLINICS
FORTHCOMING ISSUES
May 2016
August 2016
November 2016
RECENT ISSUES
November 2015
August 2015
May 2015
Preface: Modern Management of Pulmonary Metastases
The Biology of Pulmonary Metastasis
Key points
INTRODUCTION
AN OVERVIEW OF THE PATHOGENESIS OF METASTASIS
The Heterogeneity of Metastasis
The Clonality of Metastasis
SEED AND SOIL, REVISITED
THE BIOLOGY OF SUCCESSFUL METASTATIC CELLS ("SEED")
Loss of Adherence and Epithelial to Mesenchymal Transition
Cell Motility
Survival and Arrest in Transit
Extravasation
THE BIOLOGY OF THE ORGAN MICROENVIRONMENT ("SOIL")
SUMMARY
REFERENCES
Preoperative Evaluation and Indications for Pulmonary Metastasectomy
Key points
PREOPERATIVE EVALUATION
History and Physical Examination
Imaging
Mediastinal Staging
Pulmonary Function Testing
Evaluation of Extrathoracic Metastasis
Summary
INDICATIONS FOR METASTASECTOMY
Primary Malignancy Must be Controlled or Controllable
Extrathoracic Metastasis Must be Controlled or Controllable
All of the Tumor Must be Completely Resectable with Adequate Remaining Pulmonary Reserve
No Superior Alternative Nonoperative Management
SUMMARY
REFERENCES
Open Surgical Approaches for Pulmonary Metastasectomy
Key points
BACKGROUND
INTRODUCTION OF VIDEO-ASSISTED THORACIC SURGERY TECHNIQUES
POSTEROLATERAL THORACOTOMY
MUSCLE-SPARING INCISIONS
MEDIAN STERNOTOMY
EXTENDED INCISIONS
Clamshell Thoracotomy
Hemiclamshell Thoracotomy
REFERENCES
Ablative Approaches for Pulmonary Metastases
Key points
INTRODUCTION
BACKGROUND
Role of Ablative Therapies
General Principles of Ablative Therapies
ABLATIVE RADIOTHERAPY FOR PULMONARY METASTASES
Background
Technical Aspects
Clinical Results
Toxicity
Combining Ablative Radiotherapy and Systemic Therapy
Ongoing Studies
RADIOFREQUENCY ABLATION
Technique
Outcomes
MICROWAVE ABLATION
SUMMARY
REFERENCES
Lymphadenectomy During Pulmonary Metastasectomy
Key points
INTRODUCTION
INCIDENCE
LYMPH NODE SAMPLING VERSUS LYMPHADENECTOMY
PROGNOSIS
THERAPEUTIC IMPLICATIONS
SUMMARY
REFERENCES
Results of Pulmonary Resection
Key points
INTRODUCTION
PATIENT SELECTION AND OPERATIVE TECHNIQUE
NONOPERATIVE AND HYBRID TREATMENT OF PULMONARY METASTASES
PROGNOSTIC FACTORS FOR COLORECTAL PULMONARY METASTASECTOMY
SIZE AND LOCATION OF METASTASIS
NUMBER OF METASTASES
LYMPH NODE METASTASES
PREOPERATIVE CARCINOEMBRYONIC ANTIGEN LEVEL
DISEASE-FREE INTERVAL
NEW PROGNOSTIC INDICATORS
THE FUTURE
REFERENCES
Results of Pulmonary Resection
Key points
INTRODUCTION: NATURE OF THE PROBLEM
THERAPEUTIC OPTIONS AND SURGICAL TECHNIQUE
CLINICAL OUTCOMES
Sarcoma
Germ Cell Tumors
COMPLICATIONS AND CONCERNS
SUMMARY
REFERENCES
Isolated Lung Perfusion for Pulmonary Metastases
Key points
INTRODUCTION
SURGICAL TECHNIQUE
Variations of the Isolated Lung Perfusion Technique
Antegrade versus retrograde perfusion
Blood flow occlusion technique
Endovascular Blood Flow Occlusion Technique
Delayed Clamp Release
Selective Pulmonary Artery Perfusion
Hyperthermia
Video-Assisted Transcatheter Isolated Lung Perfusion
CLINICAL OUTCOMES
Doxorubicin
5-Flurodeoxyuridine
Tumor Necrosis Factor Alpha
Paclitaxel
Melphalan
Gemcitabine
Cisplatin
COMPLICATIONS AND CONCERNS
Direct Lung Injury
Systemic Toxicity
Lung to Tumor Drug Concentration
Heterogeneous Drug Distribution
SUMMARY
REFERENCES
Immunotherapy for Resected Pulmonary Metastases
Key points
BACKGROUND ON IMMUNE SYSTEM AND IMMUNOTHERAPY/IMMUNITY IN THE LUNG
MELANOMA
RENAL CELL CARCINOMA
SARCOMA
COLON CANCER
OTHER MALIGNANCIES
SUMMARY
REFERENCES
Is Surgery Warranted for Oligometastatic Disease?
Key points
THE PARADIGM OF CANCER SURGERY WITH INTENT TO CURE
DEFINING TERMS: OLIGOMETASTASIS
DEFINING TERMS: WARRANTED
DEFINING TERMS: EFFICACY AND EFFECTIVENESS
PALLIATIVE SURGERY
SURGERY INTENDED TO CURE
SURGERY TO IMPROVE SURVIVAL
A QUESTION OF ATTRIBUTION: EFFECT OF SURGERY OR OF SELECTION FOR SURGERY?
COLORECTAL CANCER AND THE DRIVE TOWARD METASTASECTOMY
LUNG METASTASECTOMY FOR COLORECTAL CANCER: THE STATE OF THE EVIDENCE
LUNG METASTASECTOMY FOR SARCOMA: THE STATE OF THE EVIDENCE
WHERE IS LUNG METASTASECTOMY HEADING?
WHY IS THERE IS ENTHUSIASM FOR METASTASECTOMY?
REFERENCES
Thoracoscopic Management of Pulmonary Metastases
Key points
INTRODUCTION
THORACOSCOPIC PULMONARY METASTASECTOMY
SURGICAL TECHNIQUE
Preoperative Planning
Preparation and Patient Positioning
Surgical Approach
Surgical Procedure
REHABILITATION AND RECOVERY
CLINICAL RESULTS IN THE LITERATURE
SUMMARY
REFERENCES
Results of Pulmonary Resection
Key points
THE ROLE OF METASTASECTOMY IN PATIENTS WITH BREAST CANCER
DIAGNOSIS
LUNG CANCER VERSUS METASTASIS BREAST CANCER
SURVIVAL
PROGNOSTIC FACTORS
PROGNOSTIC GROUPS
THE ROLE OF METASTASECTOMY IN PATIENTS WITH RENAL CELL CANCER
DIAGNOSIS
SURVIVAL
PROGNOSTIC FACTORS OF SURVIVAL
PROGNOSTIC GROUPS
LYMPH NODE DISSECTION AT LUNG METASTASECTOMY FOR RENAL CELL CANCER
REFERENCES
Thoracoscopic Lung Suffusion
Key points
INTRODUCTION
Burden of Pulmonary Metastatic Disease
Brief Overview of Suffusion
Synopsis of Competing Open or Minimally Invasive Options
Anatomy and Physiology Behind Suffusion
PRECLINICAL WORK SUPPORTING SUFFUSION
Surgical Access and Control of Pulmonary Vasculature
Uniform Selective Delivery Experiments
Preclinical Dose Selection Experiments
General Observations
Uniform Selective Delivery Experiments
Preclinical Dose Selection Experiments
SURGICAL TECHNIQUE OF LUNG SUFFUSION
Preoperative Planning
Preparation and Patient Positioning
Suffusion Procedure
Vein isolation
Ensnarement preparation
Position change to supine
Venous access
Pulmonary artery occluder placement
Vascular isolation and lung drainage
Lung suffusion
Suffusion termination
Immediate Postoperative Care
REHABILITATION AND RECOVERY
CLINICAL RESULTS IN THE LITERATURE
Overview
Illustrative Cases
Complete response of primary, second longest survival (patient 1)
Differential response to targeted therapy (patient 4) and longest survival
Differential response to targeted therapy with failure of systemic therapy (patient 10)
Long-term Outcomes of Suffusion Patients
SUMMARY
ACKNOWLEDGMENTS
SUPPLEMENTARY DATA
REFERENCES
Index

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