Regenerative Medicine, An Issue of Physical Medicine and Rehabilitation Clinics of North America

Name: Regenerative Medicine, An Issue of Physical Medicine and Rehabilitation Clinics of North America
Brand: Elsevier
Price: 86.86 EUR
Availability: OnlineOnly

Santos F. Martinez(Autor*in)

Elsevier (Verlag)

1. Auflage

Erschienen am 28. November 2016

100 Seiten

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978-0-323-47711-6 (ISBN)

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Inhalt

Intro
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
The Healing Cascade: Facilitating and Optimizing the System
Key points
Introduction
Phases of healing
Musculoskeletal tissue types: differences in healing
Factors that affect healing
Summary: strategies to facilitate and optimize healing
Dextrose Prolotherapy: A Narrative Review of Basic Science, Clinical Research, and Best Treatment Recommendations
Key points
Introduction
Methods
Results
Contraindications, side effects, and adverse events
Summary of current literature status, strength of recommendation evidence, and best treatment recommendations
Incorporating prolotherapy into practice
Platelet-Rich Plasma
Key points
Introduction
Basic science and rationale
Evidence base for musculoskeletal disorders
Patient selection and preprocedure counseling
Application of platelet-rich plasma
Summary
Stem Cell Considerations for the Clinician
Key points
Introduction
Mesenchymal stem cell definition
Food and Drug Administration regulatory guidelines
Harvesting and characterization of mesenchymal stem cells from different tissues
Effects of age and gender on mesenchymal stem cells
Mode of action of mesenchymal stem cell supplementation
Use of mesenchymal stem cells for orthopedic problems
Summary
Biocellular Regenerative Medicine: Use of Adipose-Derived Stem/Stromal Cells and It's Native Bioactive Matrix
Key points
Evolution of cell-based therapies
What is biocellular medicine?
How did biologic and cellular therapeutic concepts evolve?
"Workers and bricks" analogy
What are adipose-derived adult stem/stromal cells?
What is involved in providing biocellular regenerative therapy?
What is the future in stem/stromal cellular and biocellular treatments?
A recent advance in use of biocellular uses: nanofat (emulsified adipose derived-tissue stromal vascular fraction)
Who provides biocellular treatment?
Summary
Autologous Conditioned Serum
Key points
Introduction
Autologous conditioned serum
Discussion
Summary
a2-Macroglobulin: Autologous Protease Inhibition Technology
Key points
Introduction
a2-macroglobulin modulates the inflammatory cascade and cartilage degradation
Clinical application of a2-macroglobulin
Future directions
Performing a Better Bone Marrow Aspiration
Key points
Introduction
Basic science of stem cells
Basic science of bone marrow and bone marrow aspiration
Safety, indications, contraindications, medications, and patient preparation
Preparation for bone marrow aspiration
Technical considerations
Bone marrow aspiration step-by-step
Quick reference for ultrasound-guided bone marrow aspiration
Quick reference for fluoroscope guided bone marrow aspiration
Regenerative Approaches to Tendon and Ligament Conditions
Key points
Introduction
Tendon injury and pathophysiology
Ligament injury and pathophysiology
The use of diagnostic and interventional ultrasound
Strategies for regenerative injection therapies and augmented tendon and ligament healing
Platelet-rich plasma and autologous platelet products
Platelet lysates and platelet releasates use in augmented tendon and ligament healing
The use of stem cells in ligament and tendon injury
The use of extracellular matrix proteins and tissue scaffolding
Implantable collagen matrix for tendon healing
The use of tissue growth factors in augmented tendon and ligament healing
Other novel interventions to aid in tendon healing
Case studies: regenerative injection therapies and minimal invasive procedures for augmentation of tendon and ligament healing
Materials and methods
Treatment
Follow-up
Results
Summary
Case example 1: Achilles-placental matrix
Case example 2: shoulder (calcific rotator cuff)
Case example 3: right medial elbow pain in a college pitcher: second-degree ulnar collateral ligament sprain
Case 4: a case of chronic lateral elbow pain
Case example 5: worsening lateral elbow pain
Case example 6: mallet finger
Clinical case discussion
Summary
Orthobiologics and Knee Osteoarthritis: A Recent Literature Review, Treatment Algorithm, and Pathophysiology Discussion
Key points
Introduction
Prevalence of disease
Current orthobiologic treatment options
A new model of osteoarthritis
Systemic inflammation
Summary
Regenerative Treatments for Spinal Conditions
Key points
Introduction
Discogenic pain
Platelet rich plasma
Intradiscal platelet rich plasma
Stem cell treatments in the spine
Intradiscal fibrin injections
Future considerations
Summary
Orthopedic Surgical Options for Joint Cartilage Repair and Restoration
Key points
Introduction
Indications
Microfracture
Osteochondral autograft/mosaicplasty
Osteochondral allograft
Autologous chondrocyte implantation/matrix autologous chondrocyte implantation
Particulated juvenile articular cartilage allograft
Future directions
Summary
Rehabilitation Considerations in Regenerative Medicine
Key points
Introduction
Mechanotherapy
Mechanotransduction
Clinical integration of mechanotransduction
Summary
Index

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