Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-323-13876-5 (9780323138765)
Schweitzer Klassifikation
Preface1 Introduction: Evolutionary Design2 Conservation of Solvent Capacity and of Energy Conservation of Solvent Capacity Conservation of Energy Summary3 Functional Stoichiometric Coupling and Metabolic Prices Functional Coupling Types of Metabolic Stoichiometries The ATP Equivalent Unidirectionality Metabolic Costs of Growth Summary4 Adenylate Control and the Adenylate Energy Charge Kinetic Control of Metabolism The Adenylate Energy Charge Roles of Adenylates in Metabolism Summary5 Enzymes as Control Elements Single or Noninteracting Sites Interacting Sites and Cooperativity Graphical Representation of Enzyme Responses Basis of Cooperativity Binding Energies and Enzyme Action Summary6 Interactions between Regulatory Parameters Amphibolic Sequences Anabolic Sequences Interactions between Sequences Summary7 The Adenylate Energy Charge in Intact Cells Stability of Concentrations and Concentration Ratios Energy Charge, Adenylate Pool, and Functional Capacities Summary8 General Summary and DiscussionAppendix A Some Elementary Aspects of Thermodynamics The First Law of Thermodynamics The Second Law of ThermodynamicsAppendix B "High-Energy Bonds," Thermodynamics, and Open SystemsAppendix C The Briggs-Haldane TreatmentBibliographyIndex
