List of Abbreviations

%-RBA

relative binding affinity percentage

µFLC

microflow liquid chromatography

2d

two-dimensional

2-HG

2-hydroxyglutarate

3CLpro

3-chymotrypsin-like cysteine protease

4EBP1

Eukaryotic translation initiation factor 4E-binding protein 1

A

pre-exponential factor constant

ACE50

affinity competition experiment 50% inhibitory concentration

AChE

acetylcholinesterase

ADC

antibody-drug conjugate

ADE-OPI-MS

acoustic droplet ejection-open port interface-mass spectrometry

ADME

adsorption, distribution, metabolism, and excretion

AEMS

acoustic ejection mass spectrometry

AMI-MS

acoustic mist ionization-mass spectrometry

AMS

affinity mass spectrometry

ANSI

American National Standards Institute

APCI

atmospheric pressure chemical ionization

API

atmospheric pressure ionization

APIs

active pharmaceutical ingredients

APPI

atmospheric pressure photo ionization

ASAP

atmospheric solids analysis probe

ASMS

affinity selection mass spectrometry

ASMS

American society mass spectrometry

Asp

aspartic acid

ATD

arrival time distribution

ATP

adenosine triphosphate

AUC

analytical ultracentrifugation

AUC

area under the curve

BACC

bacterial acetyl coenzyme-A carboxylase

BACE

beta-site APP cleaving enzyme

BAMS

bead assisted mass spectrometry

Bcl-xL

B-cell lymphoma-extra large protein

bdf

batch data file

BE

buffer exchange

Bead-GPS

bead-based global proteomic screening

BFA

bound fraction analysis

BKM120

Buparlisib

BSA

bovine serum albumin

BTE

Boltzmann transport equation

C18

octadecyl stationary phase

C8

octyl stationary phase

CCS

collision cross section

CD

circular dichroism

CDMS

charge detection mass spectrometry

CEM

chain ejection model

cGAMP

cyclic GMP-ATP

cGAS

cyclic GMP-AMP synthase

CHCA

a-cyano-4-hyroxycinnamic acid

CHK1

checkpoint kinase

CID

collision induced dissociation

CIU

collision induced unfolding

CN

cyano stationary phase

CoV

compensation voltage

CPATI

cytosolic proteome and affinity-based target identification

CRIMP

Compression Ratio Ion Mobility Programming

CRM

charged residue model

CV

coefficient of variation

CYP

cytochrome P450

Da

Dalton, measurement unit used in mass spectrometry

DAR

drug-to-antibody ratio

DART

direct analysis in real time

DDI

drug-drug interaction

DEC

desorption enhancing coating

DEL

DNA-encoded library

DESI

desorption electrospray ionization

DHAP

2,5-dihydroxyacetophenone

DHFR

dihydrofolate reductase

diCQA

dicaffeoylquinic acid

DI-GCE/MS/MS

direct injection/on-line guard cartridge extraction/tandem mass spectrometry

DIMS

differential IMS

DIOS

desorption ionization on silicon

DLS

dynamic light scattering

DMA

differential mobility analyzer

DMS

differential mobility spectrometry

DP

declustering potential

DQ

DiscoveryQuant

DSF

differential scanning fluorimetry

DT

drift time

DTIMS

drift tube IMS

DUB

deubiquitilase

E a

energy of activation

ebox

electronics box

E d

bound dissociation energy

EDTA

ethylenediaminetetraacetic acid

EHDI

electrohydrodynamic ionization

EI

electron impact

EM

electron microscopy

ERK1/ERK2

extracellular signal-regulated kinase 1 and 2

ESI

electrospray ionization

ESI-MS

electrospray ionization mass spectrometry

E ?

energy associated with the vibrational wavelength

FAB

fast atom bombardment

FAIMS

high field asymmetric waveform ion mobility spectrometry

FAK

focal adhesion kinase

FASN

fatty acid synthase

FIA

flow injection analysis

FLD

fluorescence detector

FP

fluorescence polarization

FTE

full-time equivalent

FTICR

Fourier-transform ion cyclotron resonance

FWHM

full width at half maximum

GABA

?-aminobutyric

GC

gas chromatography

GLP

good laboratory practice

GPC

gel permeation chromatography

GST

glutathione S-transferase

GWAS

genome-wide association studies

HBSS

Hank's buffered salt solution

HCV

hepatitis C virus

HDMA

high-density micropatterned array

HEPES

4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid

HIC

hydrophobic interaction chromatography

HLM

human liver microsomes

HMW

high molecular weight species

HPLC

high-performance liquid chromatography

HRMS

high-resolution mass spectrometry

HT-ADME

high-throughput absorption, distribution, metabolism, excretion

HTE

high-throughput experimentation

HT-LC/MS/MS

high-throughput mass spectrometry

HT-MALDI

high-throughput matrix-assisted laser desorption/ionization

HT-MS

high-throughput mass spectrometry

HTRF

homogenous time-resolved fluorescence

HTS

high-throughput screening

IC50

half maximal inhibitory concentration

ID

internal diameter

IDH1

isocitrate dehydrogenase 1

IEX

ion exchange chromatography

IM

ion mobility

IMAC

immobilized metal ion affinity chromatography

iMALDI

immuno-matrix-assisted laser desorption/ionization

IMS

ion mobility spectrometry

IR-MALDESI

infrared matrix-assisted desorption electrospray ionization

IS

internal standards

isoAsp

isoaspartic acid

ITC

isothermal titration calorimetry

ITO

indium tin oxide

IVIVC

in vitro to in vivo correlations

k

rate constant

LC

liquid chromatography

LC/MS/MS

liquid chromatography tandem mass spectrometry

LC-MALDI

liquid chromatography-matrix-assisted laser desorption/ionization

LC-MS

liquid chromatography mass spectrometry

LDLR

low-density lipoprotein receptor

LDTD

laser diode thermal desorption

LESA

liquid extraction surface analysis

LLE

liquid-liquid extraction

LOD

limits of detection

LogD

distribution coefficient

LOQ

limit of quantitation

LPS

lipopolysaccharides

M3

microfabricated monolithic multinozzle

mAbs

monoclonal antibodies

MagMASS

magnetic microbead affinity selection screen

MALDI

matrix-assisted laser desorption ionization

MALDI-2

laser-induced postionization

MALDI-FTICR MS

matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry

MALDI-TOF MS

matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

MetAP2

methionyl aminopeptidase 2

MnESI

microflow-nanospray electrospray ionization

MPS

mesoporous silica

MRM

multiple reaction monitoring

MRO

medical review officer

MS

mass spectrometer

MS/MS

tandem mass spectrometry

MSI

mass spectrometry imaging

MTBE

methyl tert-butyl ether

MTP

microtiter plate

MuRF

muscle RING-finger protein

NADPH

nicotinamide adenine dinucleotide phosphate

NALDI

nanostructure-assisted laser desorption/ionization

Nano-DESI

nanospray desorption electrospray ionization

NAPA-LDI

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