Organic Trace Analysis by Liquid Chromatography focuses on high-performance liquid chromatography in the field of formulations analysis, which includes quality control of pharmaceutical preparations, pesticide formulations, cosmetics, and food colors. This book explores the application of liquid chromatography to trace analysis. Organized into 10 chapters, this book starts with an overview of the special requirements of liquid chromatography for trace analysis. This text then compares the approach to gas chromatography and formulations analysis, noting the significant difference. Other chapters consider the liquid chromatography equipment and examine the best types and conditions of instrumentation suitable for trace analysis. This book discusses as well the chromatography theory and includes descriptive accounts of the principles of the different forms of chromatography. The final chapter describes the typical approaches that are used for trace analysis. This book is a valuable resource for analysts engaged in the determination of trace organics in many various substrates.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-323-15702-5 (9780323157025)
Schweitzer Klassifikation
Preface1 General Considerations in Developing a Trace Analytical Technique Employing Liquid Chromatography I. Liquid Chromatography versus Gas Chromatography II. Residue Analysis versus Formulations Analysis III. Pump and Injector Requirements IV. Detectors V. Chromatography VI. Extraction and Cleanup VII. Minimum Detectable Levels VIII. Matrix Effects IX. Use of Derivatization X. Microprocessors and Automation References2 Pumping Systems I. Introduction II. Constant Volume Pumps III. Constant Pressure Pumps IV. Gradient Elution V. Comparison of Pumping Systems3 Sampling Technique and Injection Ports I. Effect of Sample Solution on Peak Shape II. Requirements for Trace Analysis III. Types of Injection Ports References4 Chromatography Columns and Packing Materials I. Requirements for Trace Analysis II. Pellicular versus Microparticulate Porous Packings III. Commercial Prepacked Columns IV. Column Packing Techniques V. Stationary-Phase Materials References5 Detectors I. Introduction II. General Detector Requirements III. Photometric Detectors IV. Electrochemical Detectors V. Solute Transport Detectors VI. Refractive Index Detectors VII. Mass Spectrometer VIII. Other Detectors References6 Chromatography Theory I. Fundamental Principles II. Adsorption Chromatography III. Partition Chromatography IV. Macroreticular Resins V. Ion-Pair Chromatography VI. Ion-Exchange Chromatography VII. Ion Chromatography VIII. Gel Permeation Chromatography IX. Ligand-Exchange Chromatography X. Charge-Transfer Chromatography References7 Chemical Derivatization I. Introduction II. UV-Absorbance Derivatization III. Fluorescence Derivatization IV. Derivatization for Other Detection Modes V. Postcolumn Reactions References8 Sample Extraction and Cleanup I. Considerations II. Sample Extraction III. Sample Cleanup IV. Column Chromatography V. Thin-Layer Chromatography VI. Distillation VII. Low-Temperature Precipitation References9 Approach to Method Development and Routine Analysis I. Choosing the Best Chromatography System II. Analysis Time and Interfering Peaks III. Qualitative and Quantitative Analysis and Confirmation IV. Automation V. Integration of LC with Other Analytical Techniques VI. LC as a Cleanup Technique References10 Applications I. Introduction II. Clinical (Biological Fluids and Tissues) III. Environmental IV. Foods ReferencesIndex
