Lung Cancer, An Issue of Surgical Oncology Clinics of North America

Name: Lung Cancer, An Issue of Surgical Oncology Clinics of North America
Brand: Elsevier
Price: 72.99 EUR
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Mark J. Krasna(Autor*in)

Elsevier (Verlag)

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Erschienen am 6. Juli 2016

100 Seiten

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Inhalt

Front Cover
Lung Cancer
Copyright
Contributors
CONSULTING EDITOR
EDITOR
AUTHORS
Contents
Foreword: Lung Cancer
Preface: Lung Cancer
Epidemiology of Lung Cancer
Classification and Pathology of Lung Cancer
Screening for Lung Cancer
Bronchoscopy: Diagnostic and Therapeutic for Non-Small Cell Lung Cancer
Mediastinal Staging in Non-Small Cell Lung Cancer
Thoracoscopic Lobectomy for Non-Small Cell Lung Cancer
Robotic Lung Resection for Non-Small Cell Lung Cancer
Pneumonectomy for Non-Small Cell Lung Cancer
Stereotactic Body Radiotherapy and Ablative Therapies for Lung Cancer
Neoadjuvant Therapy in Non-Small Cell Lung Cancer
Adjuvant Therapy for Stage I and II Non-Small Cell Lung Cancer
Targeted Therapy and Immunotherapy for Lung Cancer
Local Therapy Indications in the Management of Patients with Oligometastatic Non-Small Cell Lung Cancer
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
FORTHCOMING ISSUES
October 2016
January 2017
April 2017
RECENT ISSUES
April 2016
January 2016
October 2015
Foreword: Lung Cancer
Preface: Lung Cancer
Epidemiology of Lung Cancer
Key points
EPIDEMIOLOGIC CHARACTERISTICS
Incidence and Mortality
Survival
RISK FACTORS
Tobacco
Air Pollution
Radon
Occupational Exposure
Hereditary Susceptibility
Radiation
Diet
Others
SUMMARY
REFERENCES
Classification and Pathology of Lung Cancer
Key points
INTRODUCTION
ADENOCARCINOMA
Preinvasive or Minimally Invasive Adenocarcinoma
Invasive Adenocarcinoma
Lepidic Adenocarcinoma
Acinar Adenocarcinoma
Papillary Adenocarcinoma
Micropapillary Adenocarcinoma
Solid Adenocarcinoma
Rare Variants of Invasive Adenocarcinoma
SQUAMOUS CELL CARCINOMA
LARGE CELL CARCINOMA
OTHER NON-SMALL CELL CARCINOMA TYPES
NEUROENDOCRINE TUMORS
Typical Carcinoid
Atypical Carcinoid
Small Cell Carcinoma
Large Cell Neuroendocrine Carcinoma
OTHER PRIMARY TUMORS OF THE LUNG
BIOPSY DIAGNOSIS OF LUNG CANCER
IMMUNOHISTOCHEMISTRY
MOLECULAR TESTING OF LUNG CANCER
SUMMARY
REFERENCES
Screening for Lung Cancer
Key points
HISTORY OF LUNG CANCER SCREENING
Chest Radiograph Screening
Early Computed Tomography Screening Studies
Modeling Approaches to Estimate Mortality Benefit
The Gold Standard: the National Lung Screening Trial
IMPORTANT STATISTICAL CONCEPTS
CURRENT RECOMMENDATIONS
RESECTION OF SCREEN-DETECTED LUNG CANCER
SUMMARY
REFERENCES
Bronchoscopy
Key points
INTRODUCTION
NON-SMALL CELL LUNG CANCER
GENERAL BRONCHOSCOPY: RIGID AND FLEXIBLE
ENDOBRONCHIAL DIAGNOSIS OF NON-SMALL CELL LUNG CANCER
Endobronchial Ultrasound
Electromagnetic Navigational Bronchoscopy
Autofluorescence and Narrow Band Imaging Bronchoscopy
ENDOBRONCHIAL THERAPY FOR NON-SMALL CELL LUNG CANCER
Photodynamic Therapy
Laser Therapy
Cryotherapy
Stents
SUMMARY
REFERENCES
Mediastinal Staging in Non-Small Cell Lung Cancer
Key points
IMPORTANCE OF PRETREATMENT STAGING IN THE MANAGEMENT OF NON-SMALL CELL LUNG CANCER
THE TIMING OF MEDIASTINAL LYMPH NODE STAGING
CONSEQUENCES OF MISSED MEDIASTINAL LYMPH NODE INVOLVEMENT
BENEFITS OF PREOPERATIVE DETECTION OF MEDIASTINAL LYMPH NODE INVOLVEMENT
THE IDEAL METHOD FOR PRETREATMENT MEDIASTINAL LYMPH NODE STAGING
NONINVASIVE METHODS OF MEDIASTINAL LYMPH NODE STAGING
ENDOSCOPIC NEEDLE BIOPSY OF MEDIASTINAL LYMPH NODES
TRANSCERVICAL MEDIASTINOSCOPY
THORACOSCOPIC LYMPH NODE SAMPLING AND LYMPH NODE DISSECTION
ANTERIOR MEDIASTINOTOMY
IMAGING VERSUS BIOPSY IN MEDIASTINAL LYMPH NODE STAGING
TRANSBRONCHIAL/TRANSESOPHAGEAL NEEDLE BIOPSY VERSUS MEDIASTINOSCOPY
RESTAGING OF THE MEDIASTINUM FOLLOWING NEOADJUVANT CHEMORADIOTHERAPY
WHO SHOULD UNDERGO INVASIVE MEDIASTINAL LYMPH NODE STAGING?
SUGGESTED APPROACH TO MEDIASTINAL LYMPH NODE STAGING IN LUNG CANCER
SUMMARY
REFERENCES
Thoracoscopic Lobectomy for Non-small Cell Lung Cancer
Key points
INTRODUCTION
Video-assisted Thoracoscopic Surgery Lobectomy as an Oncologic Procedure
Advantages of Video-assisted Thoracoscopic Surgery Lobectomy
Video-assisted Thoracoscopic Surgery Lobectomy: Impact on Other Pulmonary Resections
Video-assisted Thoracoscopic Surgery Lobectomy: Development of Uniportal Video-assisted Thoracoscopic Surgery
Video-assisted Thoracoscopic Surgery Lobectomy: Development of Robotic Assisted Video-assisted Thoracoscopic Surgery
Video-assisted Thoracoscopic Surgery Lobectomy: Development of Awake Thoracoscopy
THE DUKE APPROACH
Right Upper Lobectomy
Left Upper Lobectomy
Left and Right Lower Lobectomy
SUMMARY
REFERENCES
Robotic Lung Resection for Non-Small Cell Lung Cancer
Key points
INTRODUCTION
INDICATIONS
EQUIPMENT
PREOPERATIVE EVALUATION
PORT PLACEMENT
TECHNIQUE
Right Side
Left Side
WEDGE RESECTION
THE 5 LOBECTOMIES
Right Upper Lobectomy
Right Middle Lobectomy
Right Lower Lobectomy
Left Upper Lobectomy
Left Lower Lobectomy
AVOIDANCE OF INTRAOPERATIVE COMPLICATIONS/TROUBLESHOOTING
RESULTS
Perioperative Morbidity/Mortality
Oncologic Efficacy
Lymph Node Dissection
Cost
SUMMARY
REFERENCES
Pneumonectomy for Non-Small Cell Lung Cancer
Key points
INTRODUCTION
PREOPERATIVE WORKUP
Staging
Surgical Evaluation
Cardiopulmonary Evaluation
TECHNIQUE
Left Pneumonectomy
Right Pneumonectomy
PERICARDIAL RESECTION AND RECONSTRUCTION
PERIOPERATIVE MANAGEMENT
POSTOPERATIVE COMPLICATIONS
Cardiac Complications
Atrial fibrillation
Tamponade
Patch dysfunction
Cardiac herniation
Pulmonary Complications
Acute respiratory distress syndrome
Empyema
Bronchopleural fistula
Postpneumonectomy syndrome
QUALITY OF LIFE
REFERENCES
Stereotactic Body Radiotherapy and Ablative Therapies for Lung Cancer
Key points
STEREOTACTIC BODY RADIOTHERAPY
Clinical Results
COMPARING STEREOTACTIC ABLATIVE THERAPY WITH SURGERY
STEREOTACTIC RADIOTHERAPY VS SURGERY AND RADIOSURGERY OR SURGERY FOR OPERABLE EARLY STAGE NON-SMALL CELL LUNG CANCER TRIALS
A SURGEON'S VIEW
Future Trials
Toxicity of Treatment
MICROWAVE ABLATION
RADIOFREQUENCY ABLATION
PATIENT SELECTION
Combination of Ablative Therapies
SUMMARY
REFERENCES
Neoadjuvant Therapy in Non-Small Cell Lung Cancer
Key points
INTRODUCTION
DEFINITION OF NEOADJUVANT THERAPY
EARLY STUDIES ON NEOADJUVANT THERAPY
NEOADJUVANT THERAPY VERSUS ADJUVANT THERAPY
PATIENT EVALUATION OVERVIEW
Specific Indications for Neoadjuvant Therapy
Staging and Evaluation
CHEMOTHERAPY
RADIOTHERAPY
DEVELOPING THERAPIES
EVALUATION AFTER NEOADJUVANT THERAPY
TREATMENT RESISTANCE/COMPLICATIONS
OUTCOMES AND LONG-TERM RECOMMENDATIONS
SUMMARY/DISCUSSION
REFERENCES
Adjuvant Therapy for Stage I and II Non-Small Cell Lung Cancer
Key points
INTRODUCTION
PATIENT EVALUATION OVERVIEW
Tumor Factors
TNM stage
Tumor grade and lymphatic/vascular invasion
Histology
Margin status
Single biomarkers
Prognostic signatures and cell-cycle progression biomarkers
Host Factors
Age
Comorbidity and performance status
Smoking status
Time to adjuvant chemotherapy
PHARMACOLOGIC TREATMENT OPTIONS
Cisplatin-based Adjuvant Chemotherapy
Carboplatin-based Adjuvant Chemotherapy
Neoadjuvant Chemotherapy
COMBINATION AND BIOLOGIC THERAPIES
Bevacizumab
Epidermal Growth Factor Receptor Inhibitors and Other Biologic Agents
Immunotherapy
TREATMENT OPTIONS AND COMPLICATIONS
EVALUATION OF OUTCOME AND LONG-TERM RECOMMENDATIONS
SUMMARY
ACKNOWLEDGMENTS
REFERENCES
Targeted Therapy and Immunotherapy for Lung Cancer
Key points
INTRODUCTION
TARGETED AGENTS
Background
Epidermal Growth Factor Receptor Mutations
EML4-ALK Translocations
ROS1 Rearrangements
BRAF V600 Mutations
MET Amplification or Exon 14 Skipping Mutation
RET Rearrangements
HER2 Mutations
Recommended Testing
IMMUNOTHERAPY
Background
PD-1/PD-L1 Inhibitors
CTLA-4 Inhibitors
Future Directions
SUMMARY/DISCUSSION
REFERENCES
Local Therapy Indications in the Management of Patients with Oligometastatic Non-Small Cell Lung Cancer
Key points
INTRODUCTION
STEREOTACTIC ABLATIVE RADIOTHERAPY TREATMENT PRINCIPLES
STEREOTACTIC ABLATIVE RADIOTHERAPY FOR THE MANAGEMENT OF VISCERAL METASTASES
STEREOTACTIC RADIOSURGERY FOR MANAGEMENT OF BRAIN METASTASES
SUMMARY
ACKNOWLEDGMENTS
REFERENCES

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