Biochemical and Clinical Aspects of Neuropeptides Synthesis, Processing, and Gene Structure
Erschienen am 2. Dezember 2012
330 Seiten
978-0-323-15559-5 (ISBN)
Beschreibung
Biochemical and Clinical Aspects of Neuropeptides: Synthesis, Processing, and Gene Structure covers the proceedings of the Fifth Conference on Macromolecular Synthesis: Biochemical and Clinical Aspects of Neuropeptides, held in Blankenese, Hamburg, Germany. This book is composed of seven parts encompassing 23 chapters, and begins with an introduction of the proteolytic mechanisms involved in proprotein processing, their intracellular localization, and their roles in generating a diverse assortment of secreted products in a variety of neuroendocrine cells. Part I describes the structure, synthesis, biochemical aspects, gene expression, and receptor selectivity of opioid peptides. Parts II and III focus on the isolation, structure, function, and genetic linkage of neuropeptides. The remaining parts explore the posttranslational processing, regulation, metabolism, biosynthesis, and gene expression of these neuropeptides, with a particular emphasis on their triggering mechanism and the control of release. Biochemists, neurologists, geneticists, and clinicians will greatly appreciate this book.
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Inhalt
ContributorsPrefaceIntroductionIntracellular Proteolytic Mechanisms in the Biosynthesis of Hormones and Peptide NeurotransmittersPart I: Opioid Peptides Human s-Lipotropin Biochemical Studies and Proenkephalin and the Products Derived from its Processing Expression of the Opioid Genes Receptor Selectivities of the Three Opioid Peptide FamiliesPart II: Novel Neuropeptides Structure and Function of a New Neuropeptide, the Head Activator, Controlling Head Formation in Hydra Isolation and NH2-Terminal Sequence of a Highly Conserved Pituitary and Hypothalamic Protein Belonging to a New SuperfamilyPart III: Neuropeptide Deficiencies Multiple Forms of Neuropeptides in Human CSF and their Significance Genetic Linkage Analysis in Familial Dysautonomia Using a DNA Probe for the s-Nerve Growth Factor Gene Correction of Genetic GnRH (Gonadotropin-Releasing Hormone) Deficiency in the Mouse by Preoptic Area TransplantsPart IV: Posttranslational Processing Posttranslational Processing of Gastrin/CCK Peptides in the Central Nervous System Processing in Nerves and Endocrine Cells of Peptides Related to FMRFamide and Met-Enkephalin Arg6Phe7 Biosynthesis of Peptides in Amphibian Skin Processing Signals of the Vasopressin and Oxytocin PrecursorsPart V: Regulation and Metabolites Degradation of Neuropeptides Metabolites of Arginine-Vasopressin and Oxytocin Are Highly Potent Neuropeptides in the BrainPart VI: Structure and Biosynthesis of Releasing Factors Characterization of Rat Hypothalamic Growth Hormone and Corticotropin Releasing Factors Purification Studies on Putative LHRH Precursors Tentative Identification of Luteinizing Hormone Release Hormone (LHRH)-Like Immunoreactivity among in Vitro Translation Products of Hypothalamic mRNAPart VII: Expression of Neuropeptide Genes Partial Sequence of the Rat Oxytocin Gene Regulation of Growth Hormone Gene Expression Epidermal Growth Factor mRNA Codes for a Potential Polyprotein Precursor Structure of Precursors Derived from the Sequences of Cloned cDNAsIndex
