Nutritional Toxicology Volume 2
Erschienen am 11. Juni 2013
300 Seiten
978-0-323-13830-7 (ISBN)
Beschreibung
Nutritional Toxicology, Volume II, discusses the various interactions between nutritional phenomena and toxicologic processes. It addresses particular subjects that have become substantially more important through the development of new knowledge, significant increases in knowledge, or increased awareness of potential effects on human health and well-being. The implications of such knowledge have impact on basic research, toxicity testing, public health, food, and agriculture programs, and food safety regulation. The book begins with a review of the role and importance of macro- and micronutrients on detoxification processes of foreign compounds after absorption. This is followed by separate chapters on mixed-function oxidation in the liver; the metabolic and nutritional effects of ethanol; the effects of malnutrition on drug metabolism; interaction of nutrient intake with DNA and chromatin; and how such interactions may affect the process of toxicogenesis in the nucleus. Subsequent chapters cover mutagens in cooked foods; food sensitivities; anatomical, cardiovascular, and behavioral effects of dietary caffeine; the toxicology of dietary tin, aluminum, and selenium; and the toxicology of pesticides in foods.
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Inhalt
ContributorsPrefaceContents of Volume I1 Dietary Effects on Detoxification Processes I. Introduction II. Macronutrients in Detoxification III. Micronutrients in Detoxification IV. Conclusion References2 Effect of Nutrition on Monooxygenation and Conjugation in the Liver I. Introduction II. Regulation of Mixed-Function Oxidation in the Intact Liver III. Regulation of Glucuronidation and Sulfation in the Intact Liver IV. Compartmentation of Monooxygenation and Conjugation in Periportal and Pericentral Regions of the Liver Lobule V. Future Directions References3 Metabolic and Nutritional Effects of Ethanol I. Introduction II. Metabolic Effects of Ethanol III. Nutritional Effects of Ethanol References4 Effects of Malnutrition on Drug Metabolism and Toxicity in Humans I. Introduction II. Human Malnutrition III. Dietary Effects on Drug Absorption IV. Drug-Protein Binding and Drug Distribution V. Renal Elimination of Drugs VI. Biotransformation of Drugs VII. Drug Receptors and Pharmacodynamic Responses VIII. Drug-Induced Nutritional Disorders IX. Drug-Induced Deficiencies of Water-Soluble Vitamins X. Drug-Induced Deficiencies of Fat-Soluble Vitamins XI. Antinutrient Effects of Contraceptive Steroids XII. Conclusions References5 Nutritional Influences on Chromatin: Toxicological Implications I. Introduction II. Affinity of Toxigens toward Nuclear Chromatin III. Nutritional Effects on Expression of Genes Involved in Toxigen Metabolism IV. Role of the Nucleus in Detoxification V. Future Directions References6 Mutagens in Cooked Foods I. Introduction II. Occurrence and Exposure III. Quantitation IV. Formation V. Genotoxic and Carcinogenic Effects VI. Metabolic Activation and Detoxification VII. Modifiers of Mutagenic Activity VIII. Conclusions References7 Allergic and Sensitivity Reactions to Food Components I. Introduction and Classification II. Primary Food Sensitivities III. Secondary Food Sensitivities References8 Dietary Caffeine and Its Toxicity I. Introduction II. Acute Toxicity III. Chronic Toxicity IV. Anatomical Effects V. Cardiovascular Effects VI. Behavioral Effects VII. Conclusion References9 The Toxicology of Dietary Tin, Aluminum, and Selenium I. Tin II. Aluminum III. Selenium References10 Toxicology of Pesticide Residues in Foods I. Introduction II. Mechanisms of Toxicity III. Factors Affecting the Toxicology of Pesticides in Food IV. Occurrence of Pesticide Residues in Food References11 Nutritional Importance of Pesticides I. Introduction II. Pesticide Effects on Nutrients in Foods III. General Remarks and Conclusions ReferencesIndex
