
Oxford American Handbook of Oncology (Flexicover)
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Inhalt
- Intro
- Contents
- Part 1 Background
- 1 Molecular cancer biology
- Introduction to cancer
- Molecular alterations in cancer
- Cancer biology
- 2 Etiology and epidemiology
- Genetic factors
- Smoking
- Alcohol
- Diet
- Infections
- Gender
- Sun exposure
- Other radiation exposure
- Chemical exposures
- Further reading
- Part 2 Cancer prevention and screening
- 3 Cancer prevention
- Prevention strategies: introduction
- Cancer: genetic, environmental, and infectious risks
- Smoking-related cancers
- The role of surgery in cancer prevention
- Cancer chemoprevention
- Clinical trials of cancer prevention
- Cancer prevention: diet
- Further reading
- 4 Cancer screening
- Principles
- Limitations
- Screening tests
- Further reading
- 5 Genetic screening
- Introduction
- General considerations
- Specific syndromes
- Developing issues
- Further reading and resources
- Part 3 Principles of management
- 6 Principles of cancer treatment
- 7 Surgical oncology
- General principles
- Tumor biology
- Surgical techniques
- Diagnosis and staging
- Curative surgical resection
- Palliative surgery
- Surgery for metastatic disease
- 8 Principles of radiation oncology
- Introduction
- Principles of radiobiology
- Principles of radiation physics
- External beam radiotherapy (EBRT)
- Specialized radiation therapy
- 9 Principles of chemotherapy
- Rationale for combination therapy
- Alkylating agents
- Anti-tumor antibiotics
- Antimetabolites
- Cisplatin and derivatives
- Topoisomerase inhibitors
- Antimicrotubule agents
- Drug resistance
- Dose intensification
- Chemoradiation
- 10 Hematopoietic stem cell transplantation
- Introduction
- Donor selection
- Pretransplant evaluation
- Conditioning regimens
- Post-transplant complications
- Long-term complications of HSCT
- Donor lymphocyte infusion
- 11 Hormone therapy
- Introduction
- Types of endocrine therapy
- Predictors of response
- Resistance to hormone therapy
- Controversies
- 12 Targeted therapies
- Introduction
- Small-molecule inhibitors
- Antibodies
- Conjugated agents
- Proteasome inhibitors
- Demethylation agents
- Histone deacetylase (HDAC) inhibitors
- 13 Gene therapy and immunotherapy for cancer
- Introduction
- Manipulation of tumor suppressor genes and oncogenes
- Introduction of chemotherapy sensitization and resistance genes
- Immunotherapy for cancer
- Gene delivery
- 14 Complementary and alternative medicine
- Overview of complementary and alternative medicine (CAM)
- Issues in cancer CAM
- Major categories of CAM therapies
- Further reading
- 15 Clinical trials
- Introduction
- History of clinical trials
- The ethics of clinical research
- Safety and efficacy considerations
- Phases of clinical trials
- Additional information
- Part 4 Complications and supportive care
- 16 Anemia and fatigue
- Introduction
- Overview of treatment of anemia
- Recommendations for the treatment of anemia
- Safety considerations
- Fatigue in patients with cancer
- 17 Febrile neutropenia
- Introduction
- Risk of febrile neutropenia
- Complications of febrile neutropenia
- Evaluation of the patient with febrile neutropenia
- Empiric antibiotic therapy
- Prophylaxis of febrile neutropenia
- Key point summary
- 18 Pain management
- Introduction
- Assessment
- Causes of cancer pain
- Understanding the patient's cancer pain
- Management of cancer pain
- Management of breakthrough pain
- Other pain management interventions
- Further reading
- 19 Venous thromboembolism
- Risk of venous thromboembolism (VTE)
- Consequences of VTE
- Clinical presentation
- Prevention and treatment of VTE
- Clinical practice guidelines for prophylactic anticoagulation
- Key point summary
- Thrombosis of central venous catheters
- 20 Metabolic emergencies
- Hypercalcemia
- Hyponatremia
- Hyperkalemia
- Hyperglycemia and hypoglycemia
- Acute renal failure in patients with malignant disease
- Renal tubular dysfunction
- Tumor lysis syndrome
- 21 Paraneoplastic syndromes
- Introduction
- Endocrine paraneoplastic syndromes
- Neurological paraneoplastic syndromes
- Hematological paraneoplastic syndromes
- Dermatologic and skeletal paraneoplastic syndromes
- Further reading
- 22 Superior vena cava syndrome and raised intracranial pressure
- Superior vena cava (SVC) syndrome
- Raised intracranial pressure (ICP)
- 23 Spinal cord compression
- Spinal cord compression
- 24 Other obstructive complications
- Bronchial obstruction and stridor
- Intestinal obstruction
- Obstructive jaundice
- Urinary tract obstruction
- 25 Late effects of cancer treatment
- Introduction
- Endocrine and metabolic dysfunction
- Fertility issues
- Organ-specific problems
- Secondary malignancies
- Neuropsychological consequences
- Further reading
- 26 End-of-life care
- Introduction
- Management of physical symptoms
- Management of psychosocial symptoms
- Care in the last days of life
- Further reading
- Part 5 Specific cancers
- 27 Thoracic cancers
- Lung cancer
- Non-small cell lung cancer (NSCLC)
- Surgery for NSCLC
- Chemotherapy for NSCLC
- Radiation therapy for NSCLC
- Small cell lung cancer (SCLC)
- Chemotherapy for SCLC
- Radiotherapy for SCLC
- Mesothelioma
- Thymic tumors
- 28 Breast cancer
- Introduction
- Epidemiology
- Genetics of breast cancer
- Pathology
- Prognostic factors
- Breast cancer screening
- Presentation and staging
- Management of noninvasive breast cancer
- Management of early breast cancer
- Management of locally advanced breast cancer
- Follow-up of early-stage breast cancer patients
- 29 Gastrointestinal cancer I: esophagus, stomach, small intestine, carcinoid
- Esophageal cancer
- Gastric cancer
- Small intestine and carcinoid tumors
- 30 Gastrointestinal cancer II: pancreas, biliary tract, hepatocellular
- Pancreatic cancer
- Cancers of the biliary tract
- Hepatocellular carcinoma
- 31 Gastrointestinal cancer III: colorectal, anus
- Colorectal cancer
- Anal cancer
- 32 Endocrine cancers
- Thyroid cancer
- Surgery for thyroid cancer
- Radio-iodine treatment for thyroid cancer
- External beam radiotherapy for thyroid cancer
- Chemotherapy for thyroid cancer
- Surveillance, follow-up, and prognosis for thyroid cancer
- Adrenal cancer
- Neuroblastoma
- 33 Genitourinary cancers I: renal, bladder, ureter, penile carcinomas
- Renal cancer
- Cancer of the bladder and ureter
- Penile cancer
- Further reading
- 34 Genitourinary cancers II: prostate cancer
- Prostate cancer
- Management of prostate cancer
- Treatment outcomes
- Future directions
- Further reading
- 35 Genitourinary cancers III: testicular cancer
- Testicular cancer
- Management of testicular cancer
- Follow-up
- Further reading
- 36 Gynecological cancer
- Ovarian cancer
- Cancer of the uterine corpus
- Cancer of the cervix
- Vulvar and vaginal cancer
- 37 Tumors of the central nervous system
- Primary brain tumors
- Primary CNS lymphoma
- Brain metastases
- Further reading
- 38 Head and neck cancers
- Introduction
- Etiology
- Epidemiology
- Screening and prevention
- Pathology
- Presentation
- Investigations
- Staging
- Management
- Prognosis and follow-up
- Rehabilitation
- Intraocular tumors
- Further reading
- 39 Cutaneous malignancies
- Malignant melanoma
- Management of malignant melanoma
- Intraocular melanoma
- Non-melanoma skin cancer
- Merkel cell carcinoma
- Further reading
- 40 Soft tissue and bone sarcomas
- General overview
- Soft tissue sarcomas
- Kaposi sarcoma
- Other soft tissue sarcomas
- Bone sarcomas
- Other primary bone tumors
- Surveillance
- Suggested reading
- 41 Acute leukemia
- Acute myeloid leukemia
- Acute lymphoblastic leukemia (ALL)
- 42 Chronic leukemias and myelodysplastic syndromes
- Chronic myeloid leukemia (CML)
- Myelodysplastic syndromes (MDS)
- Chronic lymphoid leukemias
- 43 Multiple myeloma
- Introduction
- Epidemiology and risk factors
- Pathogenesis
- Clinical features
- Diagnosis
- Staging and prognosis
- Treatment
- Suggested reading
- 44 Malignant lymphoma
- Hodgkin lymphoma (HL)
- Non-Hodgkin lymphomas (NHL)
- Non-Hodgkin lymphomas and acquired immunodeficiency disorder
- 45 Cancer of unknown primary (CUP)
- Clinical presentation
- Initial workup
- Metastases to lymph nodes and peritoneum
- Metastases to other sites
- Malignant pleural effusion
- Etiology, pathology, and clinical presentation of CUP
- Management of CUP
- Appendix
- Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- J
- K
- L
- M
- N
- O
- P
- Q
- R
- S
- T
- U
- V
- W
- Y
- Z
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