Cardiac Remodeling

Overview: What is Cardiac Remodeling? Structural and Mechanical Aspects of Remodeling. What Differentiates Physiological from Pathophysiologic Remodeling? Myocyte Signaling During the Transition from Hypertrophy to Heart Failure. Cardiac Myocyte Structural Remodeling. Myocyte Loss and Regeneration During Cardiac Remodeling. Role of the Interstitial Matrix in Maintaining Cardiac Function. Changes in the Interstitial Matrix During Cardiac Remodeling. Bioenergetic Abnormalities in the Remodeling Heart. Experimental Animal Models of Remodeling. The Use of Transgenic Animals to Study Cardiac Remodeling. The Effects of Pressure and Volume Load on Cardiac Structure and Remodeling. The Role of the Renin-Angiotensin Aldosterone System in Cardiac Remodeling. Adrenergic Pathways that Result in Cardiac Remodeling. Cytokines and Their Effects on Cardiac Remodeling. Other Factors Related to Cardiac Remodeling. Functional Consequences of the Remodeling Process. Epidemiology of Cardiac Remodeling. Clinical Assessment of Remodeling. Inhibition of the Renin-Angiotensin Aldosterone System. Effects of Adrenergic Blockade on Remodeling. Other Medical Therapies for Treating Cardiac Remodeling. The Effects of Cardiac Revascularization on the Remodeling Process. Valve Replacement and Repair. Cardiac Remodeling After LVAD Replacement. Cardiac Resynchronization Therapy. Other Surgical or Device-Based Approaches to Treating Cardiac Remodeling. Gene Transfer Therapy in the Treatment of Cardiac Remodeling. Future Strategies for Reversing the Remodeling Process