Bacterial Vaccines provides information dealing with vaccination of man against bacterial diseases. This book emphasizes the description, composition, production, and control of the vaccines, as well as vaccine benefits and drawbacks. Organized into 14 chapters, this book contains a description of the etiological agent, particularly with respect to its antigenic composition, and also of the pathogenesis of the disease and the immune mechanisms acting against it. The chapters are separated according to the disease they describe, which include diphtheria, tetanus, pertussis, cholera, typhoid fever, shigellosis, Escherichia coli infections, meningococcal meningitis, pneumococcal infections, Haemophilus influenzae type b infections, Pseudomonas aeruginosa infections, gonorrhea, tuberculosis, and leprosy. This book will provide the reader with a comprehensive survey of vaccination of man against bacterial diseases. It is intended for those involved in vaccine development, production, and control.
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-323-14021-8 (9780323140218)
Schweitzer Klassifikation
Contributors Preface 1 Diphtheria I. Introduction II. History of Diphtheria III. Biology of Diphtheria IV. Diphtheria Toxin and Toxoid V. Immunization against Diphtheria VI. Effect of Mass Immunization on the Epidemiology of Diphtheria VII. Conclusions and Future Prospects References 2 Tetanus I. Introduction II. The Causative Agent III. Pathogenesis IV. Clinical Features V. Epidemiology VI. Presently Available Vaccines VII. Presentation of Tetanus Vaccines VIII. Laboratory Control of Vaccines and WHO Requirements IX. Clinical Assessment of Vaccines X. Results of Field Trials Using Conventional and Overdosed Vaccines in One, Two, or Three Injections XI. Drawbacks XII. Prospects for New Vaccines References3 Pertussis I. Introduction II. Pertussis (Whooping Cough) III. Chemotherapy, Chemoprophylaxis, Pertussis Immune Globulin IV. Pertussis Vaccine V. Prospects for New Pertussis Vaccines VI. Immunization Schedules VII. Can Pertussis Be Eradicated? References 4 Cholera I. Prologue II. Introduction III. Conventional Killed Vibrio cholerae Vaccines Administered Parenterally IV. Killed Vaccines Administered Perorally V. The Pathogenesis of Cholera VI. The Cholera Enterotoxin (Choleragen or CT), Its Derivatives, and Its Relatives VII. Combined Nonliving Vaccines VIII. Live Vaccines: "Ferran and Haffkine Revisited" References5 Typhoid Fever I. Introduction II. Presently Available Vaccines III. Development of New Typhoid Vaccines IV. Live Oral Vaccines References 6 Shigellosis I. Introduction II. Characteristics of Shigellae III. Studies of Potential Vaccines in Animals IV. Studies of Potential Vaccines in Humans V. Prospects for New Vaccines References 7 Escherichia coli Infections I. Introduction II. Vaccines References 8 Meningococcal Meningitis I. Introduction II. Presently Available Vaccines III. Prospects for New Vaccines References 9 Pneumococcal Infections I. Pneumococcal Infections II. Immunity to Pneumococcal Infection III. Pneumococcal Vaccines References 10 Haemophilus influenzae Type b Infections I. Introduction II. Historical III. Description of the Organism IV. Clinical Diseases V. Vaccine Development VI. Considerations for Inclusion of Haemophilus influenzae Type b Vaccines for Routine Immunization VII. Other Vaccine Candidates References 11 Pseudomonas aeruginosa Infections I. Introduction II. Epidemiology and Clinical Significance III. Pathogenesis of Pseudomonas aeruginosa Infections IV. Currently Developed Vaccines: Clinical Status V. Human Immunity to Pseudomonas aeruginosa VI. Future Prospects: Candidate Vaccines and New Therapeutic Regimens References 12 Gonorrhea I. Introduction II. Presently Available Vaccines III. Prospects for New Vaccines References 13 Tuberculosis I. Introduction II. Presently Available Vaccines III. Prospects for New Vaccines References 14 Leprosy I. Introduction II. Causative Agent III. Clinical Manifestation IV. Pathogenesis of Lepromatous Leprosy V. Epidemiology VI. Treatment of Leprosy VII. Vaccines against Leprosy ReferencesIndex
