Concise Pediatric and Adolescent Hepatology
1. Auflage
Erschienen am 7. Mai 2012
264 Seiten
978-3-8055-9830-9 (ISBN)
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Beschreibung
Great progress in molecular biology, therapeutics, imaging as well as surgery have vastly improved the understanding and treatment of childhood liver disorders. In particular, surgical advancements in liver transplantation currently allow for a lower age or weight limit for recipients. Furthermore, the majority of children with liver disease or with liver transplantation today survive well into adulthood. In this book, world experts in the now established subspecialty of pediatric hepatology provide a comprehensive summary of the latest advances in pathophysiology, molecular diagnostics and treatment strategies. Day-to-day management of liver transplant recipients as well as psychosocial aspects and complications during the challenging transition phase to adulthood are discussed in detail. This up-to-date overview will be an invaluable tool for trainees in pediatric gastroenterology, a ready reference for busy clinicians and nurses or allied health professionals involved in the care of children with liver disease and after liver transplantation.
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05/2012
1. Auflage
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Inhalt
- Cover
- Contents
- Preface
- Growing Up with Liver Disease - Psychological Aspects of Paediatric Liver Disease
- Abstract
- Developmental Issues in Understanding Chronic Illness
- Systems Around the Child
- Common Psychological Difficulties for the Child Growing-Up with Liver Disease
- Resilience and Post-Traumatic Growth
- Key Points for Working with the Child and Family with Liver Disease
- References
- Acute Liver Failure in Children and Adolescents
- Abstract
- Definition
- Coagulopathy
- Drugs and Toxins
- Investigations
- Management
- Disease-Specific Management
- References
- Progressive Familial Intrahepatic Cholestasis in Children
- Abstract
- ATP8B1, ABCB11, and ABCB4: What They Do
- Phenotypes of Severe ATP8B1, ABCB11, and ABCB4 Disease
- Evaluation of Suspected Progressive Familial Intrahepatic Cholestasis
- References
- Biliary Atresia
- Abstract
- Epidemiology
- Aetiology
- Viruses and Biliary Atresia
- (Auto)Immune Response and Inflammation in Biliary Atresia
- Genetic Susceptibility
- Maternal Microchimerism
- Clinical Advances
- Conclusion
- References
- Alagille Syndrome
- Abstract
- Clinical Features
- Advances in Pathophysiology
- Diagnostic Challenges and Advances
- Advances in Management
- References
- Immune Deficiency-Related Liver Disease
- Abstract
- Acute Liver Disorders Related to Immune Deficiency
- Chronic Liver Disorders Related to Immune Deficiency
- Conclusions
- References
- Autoimmune Liver Disease
- Abstract
- Autoimmune Hepatitis
- Autoimmune Sclerosing Cholangitis
- References
- Wilson Disease
- Abstract
- Definition
- Pathophysiology
- Clinical Symptoms
- Diagnostic Approach
- Genotype- Phenotype Correlation
- Treatment
- Prognosis
- Conclusions
- References
- Non-Alcoholic Fatty Liver Disease in Children
- Abstract
- Clinical and Histological Aspects of Paediatric NAFLD
- Risk Factors and Epidemiology
- Pathogenesis of NAFLD
- Diagnosis
- Treatments
- Conclusions
- References
- Non-Cirrhotic Portal Hypertension
- Abstract
- Extrahepatic Portal Venous Obstruction
- Endoscopic Therapy
- Oesophageal Varices
- EHPVO Non-Bleeders
- Outcome beyond Oesophageal Variceal Eradication
- Other Issues in EHPVO
- Growth Retardation
- Portal Biliopathy
- Minimal Hepatic Encephalopathy
- Compromised Quality of Life and Hypersplenism
- Surgical Management
- Congenital Hepatic Fibrosis
- Non-Cirrhotic Portal Fibrosis
- References
- Primary Liver Malignancies: Surgical Aspects Including Transplantation
- Abstract
- Diagnostic Imaging and Histopathology
- Staging
- Chemotherapy
- Surgical Resection
- Transplantation
- Paediatric Liver Unresectable Tumour Observatory (PLUTO)
- Conclusion
- References
- Viral Hepatitis in Children
- Abstract
- Hepatitis B
- Hepatitis C
- Conclusions
- References
- Non-Viral Infections of the Liver
- Abstract
- Bacterial, Spirochaetal and Rickettsial Infections
- Fungal Infections
- Parasitic Infections
- References
- Intestinal Failure, Parenteral Nutrition and Liver Disease
- Abstract
- Definition and Expression
- Incidence and Prevalence
- Pathophysiology of Liver Disease
- Prevention of IFALD
- Conclusion
- References
- Liver Transplantation
- Abstract
- Pre-Transplant
- Peri- and Intraoperative
- Post-Transplant
- Long-Term Survival
- Conclusions
- References
- Hepatocyte Transplantation, 'Omics' and Gene Therapy in the Management of Liver Diseases
- Abstract
- Hepatocyte Transplantation
- Hepatocyte Isolation Technique
- Clinical Transplantation Procedure
- Monitoring Cell Engraftment
- Alternative Cell Sources
- Co-Culture of Hepatocytes with Stem Cells
- Techniques to Improve Liver Engraftment
- Hepatocyte Microbeads
- 'Omics' and Gene Therapy in Management of Liver Diseases
- 'Omics' (Genomics, Transcriptomics, Proteomics and Metabolomics)
- Gene Therapy
- References
- Author Index
- Subject Index
- Cover
