Microarray Gene Expression Data Analysis
A Beginner's Guide
Erschienen am 1. April 2009
176 Seiten
978-1-4443-1156-3 (ISBN)
Beschreibung
This guide covers aspects of designing microarray experiments andanalysing the data generated, including information on some of thetools that are available from non-commercial sources. Concepts andprinciples underpinning gene expression analysis are emphasised andwherever possible, the mathematics has been simplified. The guideis intended for use by graduates and researchers in bioinformaticsand the life sciences and is also suitable for statisticians whoare interested in the approaches currently used to study geneexpression.
* Microarrays are an automated way of carrying out thousands ofexperiments at once, and allows scientists to obtain huge amountsof information very quickly
* Short, concise text on this difficult topic area
* Clear illustrations throughout
* Written by well-known teachers in the subject
* Provides insight into how to analyse the data produced frommicroarrays
Rezensionen / Stimmen
"Quite a few recently published books discuss analysis ofmicroarray gene expression data for beginners. Microarray GeneExpression Data Analysis ... is arguably the best of its kindin this regard." Terry Speed, The Walter & Eliza HallInstitute of Medical Research, Nature Cell Biology, December2003 "Overall this is an excellent book, it is well referenced and,to my mind, covers the vast majority of issues an experimenterneeds to consider when venturing into the world of microarray dataanalysis. The book fills a clear gap in the field, providing arigorous overview of the often confusing .... data analysis issuesthat most books on microarrays avoid or treat in a cursory way. Iwould say it is essential reading for any laboratory or researcheractive in this rapidly evolving field and is recommended for themathematician or statisitican who is interested in the field or whohas been persuaded by their biologist colleague to help them withtheir analysis." Steven Russell, University of Cambridge,Genetical Research, February 2003 "Anyone wishing to gain a basic understanding of microarray geneexpression studies will come away enriched ... A good andaccessible entry point for any biologist who is interested ingetting an overview about how to perform microarray gene expressionstudies." D.C.Jamison, George Mason University, Heredity, June2004Weitere Details
Weitere Ausgaben
Andere Ausgaben
Helen Causton | John Quackenbush | Alvis Brazma
Microarray Gene Expression Data Analysis
A Beginner's Guide
Buch
03/2003
1. Auflage
Wiley
99,50 €
Versand in 3-4 Wochen
Personen
Helen Causton is an experimental biologist who carried outsome of the early studies on genome-wide transcriptional regulationin yeast using microarrays. She is Head of the Clinical SciencesMicroarray Centre at Imperial College, University of London.
John Quackenbush is a principal investigator at TheInstitute for Genomic Research (TIGR). His research interestsinclude development of software for microarray data analysis, geneindices and comparative genomics.
Alvis Brazma is a computer scientist who has beeninvolved in microarray data analysis since 1998. He headsmicroarray informatics at the European Bioinformatics Institute andis in charge of establishing a public repository for microarraydata.
Inhalt
Preface.
Acknowledgements.
Part I: Introduction:.
1. What Are Microarrays?.
2. Use Of Icroarrays To Monitor Gene Expression.
3. Other Uses For Microarrays.
4. Challenges Associated With The Generation Of Large Amounts OfComplex Data.
5. Future Directions.
Part II: Aspects Of Experimental Design:.
6. Features Of Microarray Data.
7. Designing The Best Experiment.
8. Preparation of Target.
9. Design of Spotted Arrays.
10. Hybridisation.
11. Long Term Considerations.
12. Verification of Results.
Part III: Data Analysis:.
13. Preliminary Processing of Data.
14. Methods for Data Analysis.
15. Graph Models.
16. Software In The Public Domain.
17. Visualisation of Data.
Part IV: Glossary:.
Index.
Colour plates fall between pp. 84 and 85.
