Guide to Genital HPV Diseases and Prevention

Preface. Overview. 1: Biology. Basic Virology. Structure. Classification and Disease Association. Genome Organization. Viral Proteins. Growth in Cell Cultures and Animal Models. Antigenicity. Pathogenesis. Molecular and Cellular Pathogenesis. Active Infection. Oncogenesis. Latency. Immunology. Humoral Response. Cellular Innate and Adaptative Response. References. 2: Epidemiology. Incidence and Prevalence. Risk Factors. HPV and Cancer, the Casual Link. Transmission and Reinfection. Natural History. References. 3: HPV Diseases. External Anogenital Warts. Other Diseases of the Anogenital Tract. Diseases of the Head and Neck Area. References. 4. Treatment. The Armamentarium. Chemical Methods. Physical Methods. Approach to Treatment. External Anogenital Warts. Other Diseases of the Anogenital Tract. Diseases of the Head and Neck Area. References. 5: Diagnosis. Cytology and Colposcopy. Histology. Nucleic Acid Detection Methods. Serology. References. 6: Screening. Screening Strategies. Appropriate Use of HPV DNA Testing. New Screnning Markers. References. 7: Prevention. Condoms and Microbicides. Vaccination. Vaccine Preclinical and Early Clinical Development. Gardasil/Silgard. Clinical Trials. Phase I Studies. Phase II Studies. Phase III and IV Studies. The Vaccine. Vaccine Recommendations. Availability. Duration of Immunity. Contraindications. Adverse Events. Cervarix. Clinical Trials. Phase I Studies. Phase II Studies. Phase III and IV Studies. The Vaccine. Vaccine Recommendations. Availability. Duration of Immunity. Contraindications. Adverse Events. Other Vaccines in Development. Benefits, Obstacles, and Strategies to Implement HPV Vaccination. Unanswered Questions. References.