Rapid Clinical Pharmacology

Preface, ix List of abbreviations, xi Basic pharmacokinetic concepts Gastrointestinal system Histamine type 2 receptor antagonists, 5 Laxatives, 6 Proton pump inhibitors (PPIs), 7 Cardiovascular system a-adrenoceptor antagonists (a blockers), 8 Adenosine, 9 Aldosterone antagonists, 10 Amiodarone, 11 Angiotensin-converting enzyme inhibitors (ACEIs), 12 Angiotensin II receptor blockers (ARBs), 13 Antimuscarinics, 14 Aspirin, 15 b-adrenoceptor antagonists (b blockers), 16 Calcium channel blockers (CCBs), 18 Cardiac glycosides, 19 Clopidogrel, 20 Dipyridamole, 21 Fibrates, 22 Fibrinolytics, 23 Flecainide, 24 Glycoprotein IIb/IIIa inhibitors, 25 Inotropic sympathomimetics, 26 Loop diuretics, 27 Low molecular weight heparins (LMWH), 28 Nitrates, 29 Potassium channel activators, 30 Statins, 31 Thiazide diuretics, 32 Tranexamic acid, 33 Vasoconstrictor sympathomimetics, 34 Warfarin, 35 Respiratory system b2 adrenoceptor agonists, 36 Histamine type 1 receptor antagonists, 37 Inhaled antimuscarinics, 38 Leukotriene receptor antagonists, 39 Oxygen, 40 Theophylline, 41 Central nervous system 5-HT1 agonists (triptans), 42 5-HT3 antagonists, 43 Antihistamine anti-emetics, 44 Antipsychotics - atypical, 45 Antipsychotics - typical, 46 Benzodiazepines, 47 Carbamazepine, 48 Dopamine antagonist anti-emetics, 49 Drugs for dementia, 50 Gabapentin and pregabalin, 51 Levodopa (L-dopa), 52 Lithium, 53 Monoamine oxidase inhibitors (MAOIs), 54 Non-steroidal anti-inflammatory drugs (NSAIDs), 55 Opioid analgesia, 56 Other antiepileptics, 57 Other antiparkinsonian drugs, 58 Paracetamol, 59 Phenothiazine anti-emetics, 60 Phenytoin, 61 Selective serotonin reuptake inhibitors (SSRIs), 62 Sodium valproate, 63 Tricyclic antidepressants (TCAs), 64 Infections Aciclovir, 65 Aminoglycosides, 66 Antifungals, 67 Antiretroviral agents, 68 Antituberculosis drugs, 69 Cephalosporins and other b lactams, 70 Penicillins, 71 Glycopeptide antibiotics, 72 Macrolides, 73 Metronidazole, 74 Nitrofurantoin, 75 Quinolones, 76 Tetracyclines, 77 Trimethoprim, 78 Endocrine system 5a-reductase inhibitors, 79 Antidiuretic hormone (ADH) analogues, 80 Biguanides, 81 Bisphosphonates, 82 Carbimazole, 83 Corticosteroids, 84 Dipeptidylpeptidase-4 (DDP-4) inhibitors, 85 Gonadotrophin-releasing hormone (GnRH) agonists, 86 Hormone replacement therapy (HRT), 87 Incretin mimetics, 88 Insulins, 89 Levothyroxine, 90 Propylthiouracil, 91 Sulfonylureas, 92 Thiazolidinediones, 93 Obstetrics, gynaecology and urinary tract disorders Contraceptives, 94 Mifepristone, 96 Oxybutynin, 97 Oxytocin, 98 Phosphodiesterase type 5 inhibitors, 99 Malignant disease and immunosuppression Alkylating agents, 100 Anthracyclines, 101 Anti-androgens, 102 Antimetabolites, 103 Antiproliferative immunosuppressants, 104 Calcineurin inhibitors, 105 Other antineoplastic drugs, 106 Selective oestrogen receptor modulators (SERMs), 107 Trastuzumab (Herceptin), 108 Vinca alkaloids, 109 Musculoskeletal and joint diseases Allopurinol, 110 Aminosalicylic acid compounds (ASAs), 111 Colchicine, 112 Methotrexate, 113 Contents vii Eye Antiglaucoma drugs, 114 Anaesthesia Depolarising neuromuscular blocking agents, 115 Etomidate, 116 Inhalational anaesthetics, 117 Lidocaine, 118 Non-depolarising blocking agents, 119 Propofol, 120 Thiopental sodium, 121 Intravenous fluids Blood and transfusion medicine Index of drugs, 127