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This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.
"The best feature of the book is the chapter summaries. These are succinct and very readable -ideal for clinicians needing a quick reference, students requiring clear and precise details about the drug's safety, or academics wanting a taste of the complexities that lie within the chapter's text. Even for just these summaries, investment in this book is worthwhile." (Nicholas Farinola, Medical Journal of Australia, Vol. 207 (4), August, 2017)
"This book has a very ambitious goal of providing an up-to-date review of a wide range of biologics used as therapeutic agents and it is clearly stated that there are many new biologics being developed that will be approved for clinical use in the near future. . this is a comprehensive compilation of information that will serve as a very useful reference book for clinicians and anyone interested in the use of biologics in medicine." (Kevin Broady, Drug Safety, Vol. 40 (7), July, 2017)
"A comprehensive, concise and up-to-date guide to approved biologic medicines predominantly produced by rDNA technology. . The chapters follow a logical sequence and are well structured; the illustrations are of high quality, and the numerous tables convey accurate and pertinent information. The book is an excellent reference text for experts in the field and biologics industry stakeholders, and as a general educational reference book for students looking to expand their knowledge in the increasingly important area of biopharmaceutical products." (Stephen Mahler, mAbs, Vol. 9 (6), July, 2017)
"Safety of Biologics Therapy: Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins . is a book that belongs on the shelf of everyone in the field of biologic therapies research and clinical practice. . an informative and easily readable book. It will be helpful for students, fellows, clinicians, and researchers who wish to improve their knowledge of the biology, pharmacological efficacy, and safety of biological drugs." (Tadeusz Robak, Biologics Targets and Therapy, Vol. 11, 2017)
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