12 Bacterial Enzymes Interacting with ?-Lactam Antibiotics.- A. Introduction.- B. Bacterial Proteins Binding ?-Lactam Antibiotics.- C. Enzymes Inhibited by ?-Lactam Antibiotics.- D. ?-Lactamases.- E. Interaction with the ?-Lactam Nucleus.- F. Concluding Remarks.- References.- 13 In Vitro and In Vivo Laboratory Evaluation of ?-Lactam Antibiotics.- A. Historical.- B. ?-Lactam Laboratory Evaluation Procedures.- C. Representative ?-Lactam Agents.- References.- 14 ?-Lactam Antibiotics: Structure-Activity Relationships.- A. Introduction: Scope.- B. Clinically Useful Penicillins.- C. Clinically Useful Cephalosporins.- D. Nonclassic ?-Lactams.- E. Other Structure-Activity Relationships.- References.- 15 Pharmacokinetics of ?-Lactam Antibiotics.- A. Introduction.- B. Penicillins.- C. Cephalosporins.- D. Other ?-Lactam Antibiotics.- References.- 16 Toxicology of ?-Lactam Antibiotics.- A. Introduction.- B. Local Reactions to Parenteral Administration.- C. Gastrointestinal Side Effects.- D. Immunologically Mediated Toxicity.- E Immune Hemolytic Anemia.- F. Neutropenia.- G. Disorders of Hemostasis.- H. Interstitial Nephritis and Cystitis.- I. Nephrotoxicity.- J. Hepatic Toxicity.- K. Neurotoxicity.- L. Disulfiram-Like Reactions.- M. Newer ?-Lactams.- References.- 17 Therapeutic Application of ?-Lactam Antibiotics.- A. Introduction.- B. Penicillins in the Therapy of Human Infections.- C. Cephalosporins in the Therapy of Human Infections.- D. Antibacterial Chemoprophylaxis with the ?-Lactam Antiobiotics.- E. Use of ?-Lactam Antibiotics in Dental Medicine.- F. Use of ?-Lactam Antibiotics in Veterinary Practice.- References.
