Fundamentals of Biochemistry Life at the Molecular Level 4E

PART I INTRODUCTION

1 Introduction to the Chemistry of Life 1

2 Water 22

PART II BIOMOLECULES

3 Nucleotides, Nucleic Acids, and Genetic Information 40

4 Amino Acids 76

5 Proteins: Primary Structure 93

6 Proteins: Three-Dimensional Structure 127

7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies 176

8 Carbohydrates 217

9 Lipids and Biological Membranes 241

10 Membrane Transport 288

PART III ENZYMES

11 Enzymatic Catalysis 315

12 Enzyme Kinetics, Inhibition, and Control 355

13 Biochemical Signaling 396

PART IV METABOLISM

14 Introduction to Metabolism 436

15 Glucose Catabolism 472

16 Glycogen Metabolism and Gluconeogenesis 517

17 Citric Acid Cycle 551

18 Electron Transport and Oxidative Phosphorylation 581

19 Photosynthesis 623

20 Lipid Metabolism 657

21 Amino Acid Metabolism 712

22 Mammalian Fuel Metabolism: Integration and Regulation 767

PART V GENE EXPRESSION AND REPLICATION

23 Nucleotide Metabolism 793

24 Nucleic Acid Structure 821

25 DNA Replication, Repair, and Recombination 867

26 Transcription and RNA Processing 919

27 Protein Synthesis 962

28 Regulation of Gene Expression 1013

Solutions to Odd-Numbered Problems SP-1

Glossary G-1

Index I-1