Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases

This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Originally, SFC was thought to be solely for low molecular weight, non-polar compounds. Today we know that SFC spans a very large polarity and molecular mass range. Modern SFC may be more adequately described as "Carbon Dioxide - Based HPLC" than "Supercritical Fluid Chromatography" and this shift in mindset and practice is a large reason for its resurgence.

Topics include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for pcSFC; Achiral pSFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC