Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters.
Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.
Rezensionen / Stimmen
"...a very comprehensive book that deals with the lung epithelial biology and molecular signaling involved in the normal lung and their implications in disease pathogenesis. It is very well written by experts in the field, highly illustrated, and presented in a very readable format. It is highly recommended for any clinician or scientist who is interested in the molecular and cellular workings of the lung. Score: 92 - 4 Stars" --Doody's
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science Publishing Co Inc
Zielgruppe
Maße
Höhe: 276 mm
Breite: 216 mm
Gewicht
ISBN-13
978-0-12-803809-3 (9780128038093)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Dr. Sidhaye is an Associate Professor at Johns Hopkins University School of Medicine. Her laboratory is interested in studying lung epithelial cellular responses in chronic lung disease, with a focus on cytoskeleton and cell-cell adhesion. The long term goal is determining lung epithelial responses in COPD and identifying if these changes promote disease and whether we can identify targets to reverse disease. Dr. Koval's laboratory works on defining the molecular machinery that regulates formation of gap junctions (which coordinate intercellular signaling) and tight junctions (which promote tissue barrier function). The long term goal of his research is understanding how junctions are pathologically misregulated in lung injury and in diseases including alcoholic lung syndrome, acute respiratory distress syndrome and cystic fibrosis.
Autor*in
Associate Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Professor, Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine and Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
1. Junctional Interplay in Lung Epithelial Barrier Function2. Ion Transport and Lung Fluid Balance3. Glucose Transport and Homeostasis in Lung Epithelia4. Pulmonary Surfactant Trafficking and Homeostasis5. Integrin Regulation of the Lung Epithelium6. Epithelial Regeneration and Lung Stem Cells7. The Function of Epithelial Cells in Pulmonary Fibrosis8. The Role of Epithelial Cell Quality Control in Health and Disease of the Distal Lung9. The Respiratory Epithelium in COPD10. Acute Respiratory Distress Syndrome11. Epithelial Barrier Dysfunction in Asthma12. Cystic Fibrosis: An Overview of the Past, Present, and the Future
