Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.
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978-0-8247-0826-9 (9780824708269)
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Schweitzer Klassifikation
Chromatographic optimization and scale-up; optimization in preparative chromatography; design, scale-up and operation of ion-exchange protein separations - mathematical modelling and case studies; analysis and scale-up of simulated moving bed (SMB)chromatography for biological purifications; large-scale ion-exchange chromatography - a comparison of different column formats; design and scale-up of pharmaceuticals in reversed phase chromatography; development and operation of a cation exchangechromatography process for large-scale purification of a recombinant F(ab)'2; scale-up challenges in the chromatography-based purification plasmid DNA; scale-up of antisense oligonucleotide purification; process separations using hydrophobic interactionchromatography.
