Malignant pleural mesothelioma, a malignancy due largely to asbestos exposure, represents an increasingly common challenge to clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, as well as researchers in the field. The disease has yet to reach its peak and is expected to kill over 100,000 people worldwide. As malignant pleural mesothelioma gains in profile, Kenneth O'Byrne and Valerie Rusch present a comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease.
The book includes chapters on epidemiology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, radiotherapy, and palliative medicine, written by an international team of contributors. A molecular biology section focuses on the carcinogenic effects of asbestos fibres and simian virus 40, angiogenesis and angiogenic growth factors, the immune response, and genetic abnormalities detected in the disease. Future therapies are also covered, as is a perspective on the distinct legal issues related to the disease. This highly-illustrated, full colour book provides the ultimate, timely resource on this devastating disease.
Rezensionen / Stimmen
...this book is one of the best. ...Anybody dealing with diffuse malignant mesothelioma, in either a research or clinical setting, should learn a great deal from this book in topics outside his or her own immediate specializations. * Respiratory Care, Vol 52, No 8, *
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Aimed at clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, palliative care physicians and specialist nurses will also be interested as well as researchers.
Illustrationen
Illustrated in full colour throughout
Maße
Höhe: 254 mm
Breite: 179 mm
Dicke: 28 mm
Gewicht
ISBN-13
978-0-19-852930-9 (9780198529309)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Dr Ken O'Byrne is President of the British Mesothelioma Trust.
Professor Valerie Rusch, M.D. is currently Chief of Thoracic Surgery at Memorial Sloan-Kettering Cancer Center, where she also holds the William G. Cahan Chair. She is a member of the Editorial Boards for The Journal of Thoracic and Cardiovascular Surgery, The Journal of Clinical Oncology, The Oncologist, and Lung Cancer.
Herausgeber*in
, Consultant Oncologist, Hope Directorate, St James's Hospital, Dublin, Ireland
, Chief of the Thoracic Service Surgery, William G Cahan Chair, Memorial Sloan-Kettering Cancer Center, New York, USA
SECTION 1. CLINICAL FEATURES OF MESOTHELIOMA ; 1. The Epidemiology and Aetiology of Malignant Mesothelioma ; 2. Epidemiological Snapshots From Around the World ; 3. Clinical Presentation, Radiological Evaluation and Diagnosis ; 4. Histopathology of Malignant Pleural Mesothelioma ; 5. Clinico-Pathological Prognostic Factors & Scoring Systems in Malignant Pleural Mesothelioma ; SECTION 2. BIOLOGY OF MESOTHELIOMA ; 6. Carcinogenic Mechanisms in Mesothelioma: Effects of asbestos on cell signal events, transcription factors, and inflammatory cytokines ; 7. Viral Factors in the Pathogenesis of Malignant Mesothelioma ; 8. Growth Factors, Cyclooxygenease-2 and Matrix Metalloproteinases in Malignant Mesothelioma ; 9. Vascularisation in Malignant Mesothelioma ; 10. Immunobiology of Malignant Mesothelioma ; 11. Cytogenetic and Molecular Genetic Changes in Malignant Mesothelioma ; SECTION 3. TREATMENT STRATEGIES ; 12. The Role of Surgery for Diagnosis, Staging and Symptom Control in Malignant Pleural Mesothelioma ; 13. Surgical and Multimodality Approaches to the Management of Operable Malignant Mesothelioma ; 14. Systemic Chemotherapy for Malignant Pleural Mesothelioma ; 15. Radiotherapy for Mesothelioma ; 16. Immunotherapy for Malignant Mesothelioma ; 17. Intra-thoracic Photodynamic Diagnosis and Treatment with Photodynamic Therapy or Hyperthermia of Malignant Mesothelioma ; 18. Novel Therapies for Mesothelioma ; 19. Gene Therapy for Malignant Pleural Mesothelioma ; 20. Palliative Care for Mesothelioma ; 21. The Treatment of Mesothelioma Cases in the American and United Kingdom Legal Systems
