Designed as a first-stop reference for researchers and professionals in toxicology, pharmacology and medicine, this handbook is the very first to tie together the knowledge from many disciplines that has so far been available only from widely dispersed sources in the primary literature. As such, it presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures.
Clearly divided into four parts, the first systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species. The second discusses the role of genetically determined metabolic malfunctions, such as galactosemia, hyperlipidemia, porphyria, hemochromatosis and related conditions, while part three looks at acquired and chronic diseases caused or exacerbated by endogenous toxins, such as hepatic injury, asthma, rheumatism, colorectal cancer, reperfusion diseases, neurodegneration and aging. The final part reviews currents strategies to control and minimize the effect of endogenous toxins, either by nutritional or pharmacological interventions.
With its complete coverage integrating molecular and systemic aspects from the biochemical basis to human disease conditions, this comprehensive reference will appeal to a broad target group of toxicologists, biochemists, nutrition specialists and physicians.
Hier erfahren Sie alles, was man momentan über endogene Toxine weiß: ihre Entstehung, ihre Wirkmechanismen, verursachte Krankheiten und sinnvolle Gegenmaßnahmen.
Auflage
Sprache
Verlagsort
Zielgruppe
Illustrationen
17
114 s/w Abbildungen, 45 s/w Tabellen, 17 farbige Abbildungen
Maße
Höhe: 24 cm
Breite: 17 cm
Dicke: 6 cm
Gewicht
ISBN-13
978-3-527-32363-0 (9783527323630)
Schweitzer Klassifikation
Peter J. O'Brien is Professor emeritus at the Department of Pharmaceutical Sciences at the University of Toronto (Canada). He obtained his academic degrees from Birmingham University (UK) and took up his first independent scientific position at the Memorial University of Newfoundland in 1967. Since 1986 he has been a full Professor at Toronto. He has more than 300 publication to his name, and was awarded the prestigious McNeil-Janssen-Ortho award for his research in 1996.
William R. Bruce is Professor emeritus at the Departments of Medical Biophysics and Nutritional Sciences at the University of Toronto (Canada). He is a fellow of the Royal Society of Canada and a former director of the American Association for Cancer Research. In 1997 he received the H. O. Warwick Prize of the National Cancer Institute of Canada for his contributions to cancer prevention.
Herausgeber*in
University of Toronto, Canada
University of Toronto, Canada
PART A: ENDOGENOUS TOXINS ASSOCIATED WITH EXCESSIVE SUGAR, FAT, RED MEAT OR ALCOHOL CONSUMPTION
1: Endogenous DNA damage
2: Modification of cysteine residues in protein
3: Endogenous macromolecule radicals
4: Alcohol-derived bioadducts
5: Iron from meat produces endogenous pro-carcinogen peroxides
6: Short chain sugars as endogenous toxins
7: Fructose-derived endogenous toxins
8: Cytotoxicity and oxidative stress induced by the glyceraldehyde-related Maillard reaction products
9: Estrogens as Endogenous Toxins
10: Reactive oxygen species (ROS), hypohalites (HOCI), and reactive nitrogen species (NOS)
PART B: GENETICS, ENDOGENOUS TOXINS ASSOCIATED WITH INBORN ERRORS OF METABOLISM
11: Oxalate and primary hyperoxaluria
12: Pathophysiology of endogenous toxins and their relation to in-born errors of metabolism and drug mediated toxicities
13: Mechanisms of toxicity in fatty acid oxidation disorders
14: Homocysteine as an endogenous toxin in cardiovascular disease
15: Uric acid alterations in cardiometabolic disorders and gout
16: Genetic defects in iron and copper trafficking
17: Polyglutamine neuropathies: Animal models to molecular mechanisms
PART C: EXAMPLES OF ENDOGENOUS TOXINS ASSOCIATED WITH ACQUIRED DISEASES OR ANIMAL DISEASE MODELS
18: Alcohol-induced hepatic injury
19: Ethanol-induced endotoxemia and tissue injury
20: Gut microbiota, diet, endotoxemia and disease
21: Nutrient derived endogenous toxins in the pathogenesis of Type 2 diabetes at the beta cell level
22: Endogenous toxins and susceptibility or resistance to diabetes complications
23: Serum advanced glycation end products associated with NASH and other liver diseases
24: Oxidative stress in the pathogenesis of hepatitis C
25: Oxidised low density lipoprotein cytotoxicity and vascular disease
26: Oxidative stress in breast cancer carcinogenesis
27: Lifestyle, endogenous toxins and colorectal cancer risk
28: Dopamine-derived neurotoxins and Parkinson's disease
29: Dopamine catabolism and Parkinson's disease: Role of a reactive aldehyde intermediate
30: Tetrahydropapaveroline, an endogenous dicatechol isoquinoline
31: Chemically-induced autoimmunity
32: Endogenous toxins associated with life expectancy and aging
PART D: THERAPEUTICS PROPOSED FOR DECREASING ENDOGENOUS TOXINS
33: Therapeutic potentials for decreasing the endogenous toxin homocysteine: Clinical trials
34: Prevention of oxidative stress-induced disease by natural dietary compounds: The mechanism of actions
35: Genotoxicity of endogenous estrogens
36: Design of nutritional interventions for control of cellular oxidation
