Executive summary * Introduction * How will NICE guidance be issued? * Steps towards implementation * Who is responsible for managing the implementation of NICE guidance? * Prioritising guidance * Assessing resource implications of guidance * Developing an action plan * Who should be involved in the implementation of NICE guidance? * Developing a local approach to implementationg guidance * Circulating guidance and publicising action plans * Using successful strategies implementation * Evaluation and audit of guidance implementation * Feedback * Appendix One: checklist and aids * Appendix Two: practical examples * Appendix Three: NICE, NPC, CHI * Appendix Four: steering group members, focus group members, other acknowledgements * Appendix Five: how this handbook was produced * Glossary