Protein Quality Control in Neurodegenerative Diseases
Erschienen am 29. Januar 2015
Buch
Softcover
XII, 136 Seiten
978-3-642-44706-8 (ISBN)
Beschreibung
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
Rezensionen / Stimmen
From the reviews:
"This is a very good cutting edge book of scholarly import on the functioning of molecules and signal transduction in both neurodegeneration and neuroprotection. . I recommend this book highly to scientists in disease pathophysiology work." (Joseph J. Grenier, Amazon.com, June, 2014)Weitere Details
Reihe
Auflage
2013
Sprache
Englisch
Verlagsort
Berlin
Deutschland
Verlagsgruppe
Springer Berlin
Zielgruppe
Für Beruf und Forschung
Research
Illustrationen
XII, 136 p.
Maße
Höhe: 235 mm
Breite: 155 mm
Dicke: 9 mm
Gewicht
236 gr
ISBN-13
978-3-642-44706-8 (9783642447068)
DOI
10.1007/978-3-642-27928-7
Schweitzer Klassifikation
Weitere Ausgaben
Andere Ausgaben
Richard I. Morimoto | Yves Christen
Protein Quality Control in Neurodegenerative Diseases
E-Book
12/2012
1. Auflage
Springer
149,79 €
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Richard I. Morimoto | Yves Christen
Protein Quality Control in Neurodegenerative Diseases
Buch
12/2012
1. Auflage
Springer
160,49 €
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Inhalt
The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto.- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron.- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin.- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen.- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo.- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima.- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl.- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner.- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri.- Subject code.