Overview.- Introduction: Summary.- Definition.- Epidemiology.- Risk Factors.- Pathology/Pathogenesis/Pathophysiology.- Assessment.- Introduction: Summary.- Symptoms: SGRQ, CAT, MRC.- Spirometry.- Images.- Biomarkers.- Comorbidity.- Heterogeneity.- Introduction: Summary.- Phenotypes of COPD.- Genetics.- Images.- ACOS.- Exacerbation.- Pulmonary Hypertension.- Management.- Introduction: Summary.- Prevention.- Pharmacologic.- Non-pharmacologic: LVR, Rehab, Nutritional support.- Management of exacerbation.- Management of Comorbidities.- Personalized Treatment: current practice and evidences from researches.- Prospective.- Cohort: KOLD, ANOLD; Big data, Network medicine.
